JPS5210877B2 - - Google Patents
Info
- Publication number
- JPS5210877B2 JPS5210877B2 JP47111219A JP11121972A JPS5210877B2 JP S5210877 B2 JPS5210877 B2 JP S5210877B2 JP 47111219 A JP47111219 A JP 47111219A JP 11121972 A JP11121972 A JP 11121972A JP S5210877 B2 JPS5210877 B2 JP S5210877B2
- Authority
- JP
- Japan
- Prior art keywords
- novel compounds
- alkoxy
- pharmaceutical
- convulsant
- styryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004050 homopiperazines Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000005504 styryl group Chemical group 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
1416412 Piperazine and homopiperazine derivatives HOKURIKU PHARMACEUTICAL CO Ltd 7 Jan 1974 [8 Oct 1973 (3)] 00588/74 Heading C2C Novel compounds I (in which R is phenyl substituted with one or more of C 1-6 alkyl, C 1-6 alkoxy and halogen; or styryl or pyridyl optionally substituted with one or more C 1-6 alkoxy groups and n and m are 2 or 3) and salts thereof, are prepared by esterification of an alcohol of Formula (II) or a salt thereof, with an appropriate acid. Pharmaceutical compositions having analgesic, coronary vasodilative, anti-convulsant and blood pressure decreasing properties comprise one of the above novel compounds together with a pharmaceutically acceptable vehicle or diluent.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP47111219A JPS5210877B2 (en) | 1972-11-08 | 1972-11-08 | |
| JP48112289A JPS5224031B2 (en) | 1972-11-08 | 1973-10-08 | |
| DE19732355420 DE2355420A1 (en) | 1972-11-08 | 1973-11-06 | NEW PIPERAZINE OR HOMOPIPERAZINE MONOAL CANOLESTERS AND THE METHOD FOR THEIR PRODUCTION |
| FR7340568A FR2205515B1 (en) | 1972-11-08 | 1973-11-07 | |
| BE137507A BE807031A (en) | 1972-11-08 | 1973-11-07 | NEW PIPERAZINE- OR HOMOPIPERAZINE MONOALKANOL-ESTERS AND THEIR PREPARATION PROCESS |
| ES420389A ES420389A1 (en) | 1972-11-08 | 1973-11-08 | A procedure for the production of a new ester piperazinu homopiperazin-monoalcanolico. (Machine-translation by Google Translate, not legally binding) |
| GB58874A GB1416412A (en) | 1972-11-08 | 1974-01-07 | Piperazinyl-and monopiperazinyl monoalkanol esters and a process of production thereof |
| CA189,574A CA1055492A (en) | 1972-11-08 | 1974-01-07 | Piperazine-and homopiperazine-monoalkanol esters and a process of production thereof |
| SE7400215A SE398502B (en) | 1972-11-08 | 1974-01-08 | PROCEDURE FOR THE PREPARATION OF PIPERAZINE AND HOMOPIPERAZINE PROPANOLE ESTERS WITH THERAPEUTIC EFFECT |
| AT13574*#A AT333287B (en) | 1972-11-08 | 1974-01-09 | METHOD FOR MANUFACTURING NEW PIPERAZINE OR HOMOPIPERAZINE MONOALCANOLESTERS |
| NL7400278A NL7400278A (en) | 1972-11-08 | 1974-01-09 | PROCEDURE FOR CREATING NEW PIPER OR HOMOPIPERAZINE MONOALKANOL ESTERS IN A THERAPEUTICALLY SUITABLE FORMING, AND PROCEDURES FOR MAKING THESE CONNECTIONS. |
| CH191374A CH591465A5 (en) | 1972-11-08 | 1974-02-12 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP47111219A JPS5210877B2 (en) | 1972-11-08 | 1972-11-08 | |
| JP48112289A JPS5224031B2 (en) | 1972-11-08 | 1973-10-08 | |
| JP11229073A JPS5246235B2 (en) | 1973-10-08 | 1973-10-08 | |
| JP11229173A JPS5224032B2 (en) | 1973-10-08 | 1973-10-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS49132088A JPS49132088A (en) | 1974-12-18 |
| JPS5210877B2 true JPS5210877B2 (en) | 1977-03-26 |
Family
ID=27469891
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP47111219A Expired JPS5210877B2 (en) | 1972-11-08 | 1972-11-08 | |
| JP48112289A Expired JPS5224031B2 (en) | 1972-11-08 | 1973-10-08 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP48112289A Expired JPS5224031B2 (en) | 1972-11-08 | 1973-10-08 |
Country Status (10)
| Country | Link |
|---|---|
| JP (2) | JPS5210877B2 (en) |
| AT (1) | AT333287B (en) |
| BE (1) | BE807031A (en) |
| CA (1) | CA1055492A (en) |
| CH (1) | CH591465A5 (en) |
| DE (1) | DE2355420A1 (en) |
| FR (1) | FR2205515B1 (en) |
| GB (1) | GB1416412A (en) |
| NL (1) | NL7400278A (en) |
| SE (1) | SE398502B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU173380B (en) * | 1977-02-25 | 1979-04-28 | Richter Gedeon Vegyeszet | Process for producing new pyridyl-piperazine derivatives and acid additional salts thereof |
| JPS53144591A (en) * | 1977-05-20 | 1978-12-15 | Asutaabueruke Ag Chem Fuaburii | Process for preparing homopirerazine |
| DE3403778A1 (en) * | 1984-02-03 | 1985-08-08 | Degussa Ag, 6000 Frankfurt | CYANOMETHYL- (2-CYANO-ETHYL) - (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2088019A1 (en) * | 1970-05-08 | 1972-01-07 | Rabot Ets David | Esters of 2 and 6-substituted nicotinic acids - with vasomotor active |
| FR2088018A1 (en) * | 1970-05-03 | 1972-01-07 | Rabot Ets David | Vasodilatory, substd nicotinic acid amino ester derivs |
| FR2134121A1 (en) * | 1971-04-20 | 1972-12-08 | Penciolelli Madeleine | Piperazino ethyl phloroglucates prepn - useful as vasodilators |
-
1972
- 1972-11-08 JP JP47111219A patent/JPS5210877B2/ja not_active Expired
-
1973
- 1973-10-08 JP JP48112289A patent/JPS5224031B2/ja not_active Expired
- 1973-11-06 DE DE19732355420 patent/DE2355420A1/en not_active Ceased
- 1973-11-07 BE BE137507A patent/BE807031A/en unknown
- 1973-11-07 FR FR7340568A patent/FR2205515B1/fr not_active Expired
-
1974
- 1974-01-07 CA CA189,574A patent/CA1055492A/en not_active Expired
- 1974-01-07 GB GB58874A patent/GB1416412A/en not_active Expired
- 1974-01-08 SE SE7400215A patent/SE398502B/en unknown
- 1974-01-09 NL NL7400278A patent/NL7400278A/en not_active Application Discontinuation
- 1974-01-09 AT AT13574*#A patent/AT333287B/en not_active IP Right Cessation
- 1974-02-12 CH CH191374A patent/CH591465A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2355420A1 (en) | 1974-07-04 |
| BE807031A (en) | 1974-03-01 |
| GB1416412A (en) | 1975-12-03 |
| FR2205515A1 (en) | 1974-05-31 |
| AT333287B (en) | 1976-11-10 |
| JPS5062983A (en) | 1975-05-29 |
| CA1055492A (en) | 1979-05-29 |
| FR2205515B1 (en) | 1978-11-17 |
| SE7400215L (en) | 1975-04-16 |
| SE398502B (en) | 1977-12-27 |
| NL7400278A (en) | 1975-04-10 |
| ATA13574A (en) | 1976-03-15 |
| JPS49132088A (en) | 1974-12-18 |
| JPS5224031B2 (en) | 1977-06-28 |
| CH591465A5 (en) | 1977-09-15 |
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