JPS5212172A - Process for preparation of novel ortho- nitrobutyrophenone derivatives - Google Patents

Process for preparation of novel ortho- nitrobutyrophenone derivatives

Info

Publication number
JPS5212172A
JPS5212172A JP50087962A JP8796275A JPS5212172A JP S5212172 A JPS5212172 A JP S5212172A JP 50087962 A JP50087962 A JP 50087962A JP 8796275 A JP8796275 A JP 8796275A JP S5212172 A JPS5212172 A JP S5212172A
Authority
JP
Japan
Prior art keywords
nitrobutyrophenone
derivatives
preparation
novel ortho
ortho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP50087962A
Other languages
Japanese (ja)
Other versions
JPS5922702B2 (en
Inventor
Kikuo Sasajima
Keiichi Ono
Yasuo Motoike
Shigeo Inaba
Hisao Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP50087962A priority Critical patent/JPS5922702B2/en
Priority to FI762035A priority patent/FI60559C/en
Priority to CA257,086A priority patent/CA1084500A/en
Priority to CS78865A priority patent/CS192499B2/en
Priority to CS78866A priority patent/CS192500B2/en
Priority to CS764704A priority patent/CS192466B2/en
Priority to DK324176A priority patent/DK324176A/en
Priority to AU15978/76A priority patent/AU499080B2/en
Priority to SE7608152A priority patent/SE7608152L/en
Priority to MX177876U priority patent/MX3747E/en
Priority to FR7621896A priority patent/FR2317924A1/en
Priority to NO762505A priority patent/NO762505L/no
Priority to US05/705,840 priority patent/US4075346A/en
Priority to BE168969A priority patent/BE844209A/en
Priority to SU762381097A priority patent/SU741792A3/en
Priority to GB29998/76A priority patent/GB1527783A/en
Priority to NL7607993A priority patent/NL7607993A/en
Priority to CH922076A priority patent/CH624937A5/de
Priority to DE19762632414 priority patent/DE2632414A1/en
Publication of JPS5212172A publication Critical patent/JPS5212172A/en
Publication of JPS5922702B2 publication Critical patent/JPS5922702B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE: Ortho-Nitrobutyrophenone derivatives of formula I [where R is H, halogen, lower alkyl, lower lakoxy, CF3; Z is II (the dotted line is a single bond or double bond; when the bond of piperidine ring at the 3, 4-positions is saturated, R1 is H or OH; R2 is H, halogen, lower alkyl, phenyl or benzyl substituted by lower alkoxy or CF3), III, IV, V, VI, etc.].
COPYRIGHT: (C)1977,JPO&Japio
JP50087962A 1972-03-24 1975-07-17 Method for producing novel ortho-nitrobutylphenone derivatives Expired JPS5922702B2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP50087962A JPS5922702B2 (en) 1975-07-17 1975-07-17 Method for producing novel ortho-nitrobutylphenone derivatives
FI762035A FI60559C (en) 1975-07-17 1976-07-13 FOERFARANDE FOER FRAMSTAELLNING AV NY- (TERTIAER AMINO) -ORTO-AMINOBUTYROFENONFOERENINGAR
CA257,086A CA1084500A (en) 1975-07-17 1976-07-15 Method for preparing ortho-aminobutyrophenone derivatives and salts thereof
CS78865A CS192499B2 (en) 1975-07-17 1976-07-15 Method of preparing gama-/secondary amino/-o-aminobutyrophenone compounds
CS78866A CS192500B2 (en) 1975-07-17 1976-07-15 Method of preparing gama-/secondary amino/-o-aminobutyrophenone compounds
CS764704A CS192466B2 (en) 1975-07-17 1976-07-15 Process for preparing gamma-/secondary amino/-o-nitro-butyrophenonic compounds
DK324176A DK324176A (en) 1975-07-17 1976-07-16 PROCEDURE FOR THE PREPARATION OF ORTHOAMINOBUTYROPHENONE DERIVATIVES
AU15978/76A AU499080B2 (en) 1975-07-17 1976-07-16 Ortho-aminobutyrophenone derivatives and salts thereof
SE7608152A SE7608152L (en) 1975-07-17 1976-07-16 NEW METHOD FOR THE PREPARATION OF ORTO-AMINOBUTYROFENONE DERIVATIVES AND SALTS THEREOF
MX177876U MX3747E (en) 1972-03-24 1976-07-16 IMPROVED METHOD FOR PRODUCING A STEEL ALLOY PROCEDURE FOR THE PRODUCTION OF GAMMA DERIVATIVES (SECONDARY AMINO) -ORTO / AMINO BUTIROFENONAS AND ITS SALTS
FR7621896A FR2317924A1 (en) 1975-07-17 1976-07-16 PROCESS FOR THE PRODUCTION OF ORTHO-AMINOBUTYROPHENONE DERIVATIVES, NEW PRODUCTS THUS OBTAINED AND THEIR USE AS ANALGESIC AND ANTIPSYCHOSIS AGENTS
NO762505A NO762505L (en) 1975-07-17 1976-07-16
US05/705,840 US4075346A (en) 1975-07-17 1976-07-16 CNS depressant γ-(secondary amino)-ortho-nitro-butyrophenones
BE168969A BE844209A (en) 1975-07-17 1976-07-16 NEW PROCESS FOR THE PREPARATION OF ORTHO-AMINO-BUTYROPHENONES AND THEIR SALTS
SU762381097A SU741792A3 (en) 1975-07-17 1976-07-16 Method of preparing derivatives of gamma-(sec-amino)o-nitrobutyrophenone or its salts
GB29998/76A GB1527783A (en) 1975-07-17 1976-07-19 Butyrophenone derivatives
NL7607993A NL7607993A (en) 1975-07-17 1976-07-19 ORTHO-AMINOBUTYROPHENE DERIVATIVES.
CH922076A CH624937A5 (en) 1975-07-17 1976-07-19
DE19762632414 DE2632414A1 (en) 1975-07-17 1976-07-19 O-NITROBUTYROPHENONE AND METHOD FOR PREPARING O-AMINOBUTYROPHENONE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50087962A JPS5922702B2 (en) 1975-07-17 1975-07-17 Method for producing novel ortho-nitrobutylphenone derivatives

Publications (2)

Publication Number Publication Date
JPS5212172A true JPS5212172A (en) 1977-01-29
JPS5922702B2 JPS5922702B2 (en) 1984-05-28

Family

ID=13929474

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50087962A Expired JPS5922702B2 (en) 1972-03-24 1975-07-17 Method for producing novel ortho-nitrobutylphenone derivatives

Country Status (4)

Country Link
JP (1) JPS5922702B2 (en)
BE (1) BE844209A (en)
CS (3) CS192466B2 (en)
SU (1) SU741792A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS632457U (en) * 1986-06-21 1988-01-09

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3209006A (en) * 1959-05-01 1965-09-28 May & Baker Ltd Phenylpiperidine and phenyltetrahydropyridine compounds
US3438991A (en) * 1959-11-18 1969-04-15 Res Lab Dr C Janssen Nv 1-aroylalkyl derivatives of arylhydroxypyrrolidines and arylhydroxy-piperidines
US3476762A (en) * 1966-12-27 1969-11-04 Aldrich Chem Co Inc 4' - dimethylamino - 4 - (4 - hydroxy-4-phenyl piperidino)butyrophenones and 4 - (4-phenyl-4-hydroxy - piperidino)-1,1-ethylenedioxy - 1 - (4 - dimethylaminophenyl)butanes
JPS4914476A (en) * 1972-06-07 1974-02-07

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3209006A (en) * 1959-05-01 1965-09-28 May & Baker Ltd Phenylpiperidine and phenyltetrahydropyridine compounds
US3438991A (en) * 1959-11-18 1969-04-15 Res Lab Dr C Janssen Nv 1-aroylalkyl derivatives of arylhydroxypyrrolidines and arylhydroxy-piperidines
US3476762A (en) * 1966-12-27 1969-11-04 Aldrich Chem Co Inc 4' - dimethylamino - 4 - (4 - hydroxy-4-phenyl piperidino)butyrophenones and 4 - (4-phenyl-4-hydroxy - piperidino)-1,1-ethylenedioxy - 1 - (4 - dimethylaminophenyl)butanes
JPS4914476A (en) * 1972-06-07 1974-02-07

Also Published As

Publication number Publication date
CS192499B2 (en) 1979-08-31
JPS5922702B2 (en) 1984-05-28
BE844209A (en) 1977-01-17
SU741792A3 (en) 1980-06-15
CS192500B2 (en) 1979-08-31
CS192466B2 (en) 1979-08-31

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