JPS5285159A - Novel steroid compound - Google Patents

Novel steroid compound

Info

Publication number
JPS5285159A
JPS5285159A JP30477A JP30477A JPS5285159A JP S5285159 A JPS5285159 A JP S5285159A JP 30477 A JP30477 A JP 30477A JP 30477 A JP30477 A JP 30477A JP S5285159 A JPS5285159 A JP S5285159A
Authority
JP
Japan
Prior art keywords
steroid compound
novel steroid
novel
compound
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP30477A
Other languages
English (en)
Japanese (ja)
Inventor
Hanrei Fuiritsupusu Goodon
Jiyon Mei Piitaa
Edowaado Eiruzu Barii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of JPS5285159A publication Critical patent/JPS5285159A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/0025—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
    • C07J7/003—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP30477A 1976-01-06 1977-01-05 Novel steroid compound Pending JPS5285159A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB357/76A GB1570394A (en) 1976-01-06 1976-01-06 11-acyloxy-3-hydroxy steroids

Publications (1)

Publication Number Publication Date
JPS5285159A true JPS5285159A (en) 1977-07-15

Family

ID=9702974

Family Applications (1)

Application Number Title Priority Date Filing Date
JP30477A Pending JPS5285159A (en) 1976-01-06 1977-01-05 Novel steroid compound

Country Status (12)

Country Link
JP (1) JPS5285159A (fr)
AU (1) AU513579B2 (fr)
BE (1) BE850108A (fr)
CA (1) CA1084903A (fr)
DE (1) DE2700267A1 (fr)
DK (1) DK3577A (fr)
FR (1) FR2361419A1 (fr)
GB (1) GB1570394A (fr)
NL (1) NL7700054A (fr)
NZ (1) NZ183004A (fr)
SE (1) SE7700098L (fr)
ZA (1) ZA7759B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016525121A (ja) * 2013-07-19 2016-08-22 セージ セラピューティクス， インコーポレイテッド 向神経活性ステロイド、組成物、およびそれらの使用
US10709505B2 (en) 2015-06-10 2020-07-14 Boston Scientific Corporation Bodily substance detection by evaluating photoluminescent response to excitation radiation
JP2021506904A (ja) * 2017-12-22 2021-02-22 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ障害の処置のための組成物および方法
JP2022105088A (ja) * 2016-07-11 2022-07-12 セージ セラピューティクス， インコーポレイテッド Ｃ７、ｃ１２、およびｃ１６置換神経刺激性ステロイドおよびそれらの使用方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ300694A3 (en) * 1993-12-02 1996-05-15 Akzo Nobel Nv Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
GB0105772D0 (en) * 2001-03-08 2001-04-25 Sterix Ltd Use
CA3152410A1 (en) 2011-10-14 2013-04-18 Sage Therapeutics, Inc. 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders
SMT202000008T1 (it) 2012-01-23 2020-03-13 Sage Therapeutics Inc Formulazione di steroide neuroattivo comprendente un complesso di allopregnanolone e solfobutil eter beta-ciclodestrina
PL2887944T3 (pl) 2012-08-21 2022-02-21 Sage Therapeutics, Inc. Allopregnanolon do leczenia lekoopornego stanu padaczkowego
WO2014169831A1 (fr) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor-hétéroaryl-stéroïdes c21-c-liés c3,3-disubstitués et procédés d'utilisation de ceux-ci
CN113527400B (zh) 2013-04-17 2024-06-28 萨奇治疗股份有限公司 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法
RU2019126333A (ru) 2013-04-17 2019-10-08 Сейдж Терапьютикс, Инк. 19-нор нейроактивные стероиды и способы их применения
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
AU2014308621C1 (en) 2013-08-23 2022-01-06 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2015195962A1 (fr) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Stéroïdes neuroactifs, leurs compositions et utilisations
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
SMT202000414T1 (it) 2014-10-16 2020-09-10 Sage Therapeutics Inc Composizioni e metodi per trattare disturbi del snc
MX2021004492A (es) 2014-10-16 2022-12-05 Sage Therapeutics Inc Composiciones para el tratamiento de trastornos del snc.
ME03749B (fr) 2014-11-27 2021-04-20 Sage Therapeutics Inc Compositions et procédés pour traiter des troubles du snc
DK3250210T3 (da) 2015-01-26 2021-03-08 Sage Therapeutics Inc Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser
JP6875996B2 (ja) 2015-02-20 2021-05-26 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド、組成物、およびその使用
RU2766155C2 (ru) 2016-03-08 2022-02-08 Сейдж Терапьютикс, Инк. Нейроактивные стероиды, их композиции и применения
WO2018013613A1 (fr) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
IL312610B2 (en) 2018-12-05 2026-05-01 Sage Therapeutics Llc Neuroactive steroids and methods of using them
CN114206900A (zh) 2019-05-31 2022-03-18 萨奇治疗股份有限公司 神经活性类固醇及其组合物
EP3990468A1 (fr) * 2019-06-27 2022-05-04 Sage Therapeutics, Inc. Composés pour le traitement de troubles du système nerveux central
WO2020264495A1 (fr) * 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions et méthodes de traitement de troubles du système nerveux central
TWI896547B (zh) 2019-06-27 2025-09-11 美商賽吉醫療公司 用於治療cns病症之組合物及方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016525121A (ja) * 2013-07-19 2016-08-22 セージ セラピューティクス， インコーポレイテッド 向神経活性ステロイド、組成物、およびそれらの使用
JP2019142981A (ja) * 2013-07-19 2019-08-29 セージ セラピューティクス， インコーポレイテッド 向神経活性ステロイド、組成物、およびそれらの使用
US10709505B2 (en) 2015-06-10 2020-07-14 Boston Scientific Corporation Bodily substance detection by evaluating photoluminescent response to excitation radiation
JP2022105088A (ja) * 2016-07-11 2022-07-12 セージ セラピューティクス， インコーポレイテッド Ｃ７、ｃ１２、およびｃ１６置換神経刺激性ステロイドおよびそれらの使用方法
JP2021506904A (ja) * 2017-12-22 2021-02-22 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ障害の処置のための組成物および方法

Also Published As

Publication number Publication date
NZ183004A (en) 1980-03-05
FR2361419A1 (fr) 1978-03-10
AU2106577A (en) 1978-07-13
FR2361419B1 (fr) 1980-04-04
ZA7759B (en) 1978-02-22
GB1570394A (en) 1980-07-02
NL7700054A (nl) 1977-07-08
AU513579B2 (en) 1980-12-11
DE2700267A1 (de) 1977-07-14
CA1084903A (fr) 1980-09-02
DK3577A (da) 1977-07-07
BE850108A (fr) 1977-07-05
SE7700098L (sv) 1977-07-07

Similar Documents

Publication Publication Date Title
JPS5368786A (en) Heterocycltc compound
JPS52151348A (en) Compound
JPS5363424A (en) Bitumious compound
JPS52125197A (en) Transshexahydroopyridooindole compound
JPS5395993A (en) Novel 88azapurinee88one compound
JPS5359686A (en) Compound
AU2142677A (en) Steroids
JPS5353618A (en) Nnsubstituted biscarbamoylsulfide compound
JPS5295689A (en) Betaalactummcontaining compound
JPS55127390A (en) Aryltrifluoroethylamine compound
JPS5325537A (en) Compound
JPS5323995A (en) Antiibacterial compound
JPS5293772A (en) Indolinospiropyran compound
JPS5716827A (en) Novel compound
JPS52148062A (en) Steroids
JPS52156899A (en) Compound
JPS5337653A (en) 111deoxyy111oxaprostaglandin compound
JPS5321222A (en) Bissbenzoxazolyl compound
JPS5473826A (en) New compound
JPS5353692A (en) Antiiworm compound
JPS539793A (en) Novel cephlosporin compound
JPS536416A (en) 55fluorouracli inclusion compound
JPS55102588A (en) Tetraselenapentalene compound
JPS5297957A (en) Novel steroid compound
JPS52125158A (en) Oxothia compound