JPS5359681A - Method of fluorination - Google Patents
Method of fluorinationInfo
- Publication number
- JPS5359681A JPS5359681A JP13436776A JP13436776A JPS5359681A JP S5359681 A JPS5359681 A JP S5359681A JP 13436776 A JP13436776 A JP 13436776A JP 13436776 A JP13436776 A JP 13436776A JP S5359681 A JPS5359681 A JP S5359681A
- Authority
- JP
- Japan
- Prior art keywords
- fluorination
- fluorouracil
- fluorine
- readily
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003682 fluorination reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- -1 aliphatic fatty acid Chemical class 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229960002949 fluorouracil Drugs 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Abstract
PURPOSE: In obtaining 5-fluorouracil useful as anticancer agent and its intermediate by reacting uracil with fluorine in HF medium, higher product yield can readily be achieved by the use of an aliphatic fatty acid as nucleophilic agent.
COPYRIGHT: (C)1978,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP51134367A JPS6016431B2 (en) | 1976-11-09 | 1976-11-09 | Fluorination method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP51134367A JPS6016431B2 (en) | 1976-11-09 | 1976-11-09 | Fluorination method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5359681A true JPS5359681A (en) | 1978-05-29 |
| JPS6016431B2 JPS6016431B2 (en) | 1985-04-25 |
Family
ID=15126709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51134367A Expired JPS6016431B2 (en) | 1976-11-09 | 1976-11-09 | Fluorination method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6016431B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631342A (en) * | 1984-03-09 | 1986-12-23 | Onoda Cement Company, Ltd. | Process for producing 5-fluorouracil |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63100430U (en) * | 1986-12-16 | 1988-06-29 | ||
| JPH0194321U (en) * | 1987-12-11 | 1989-06-21 |
-
1976
- 1976-11-09 JP JP51134367A patent/JPS6016431B2/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631342A (en) * | 1984-03-09 | 1986-12-23 | Onoda Cement Company, Ltd. | Process for producing 5-fluorouracil |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6016431B2 (en) | 1985-04-25 |
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