JPS539312A - Preparation of light-stable mecobalamin or cobamamide parenteral injections - Google Patents

Preparation of light-stable mecobalamin or cobamamide parenteral injections

Info

Publication number: JPS539312A
Authority: JP; Japan
Prior art keywords: mecobalamin; light; cobamamide; stable; preparation
Prior art date: 1976-07-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP8161176A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5543446B2 (2

Inventor

Wataru Kato

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sankyo Co Ltd

Original Assignee

Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-07-09

Filing date

1976-07-09

Publication date

1978-01-27

1976-07-09 Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd

1976-07-09 Priority to JP8161176A priority Critical patent/JPS539312A/ja

1978-01-27 Publication of JPS539312A publication Critical patent/JPS539312A/ja

1980-11-06 Publication of JPS5543446B2 publication Critical patent/JPS5543446B2/ja

Status Granted legal-status Critical Current

Links

229960005321 mecobalamin Drugs 0.000 title abstract 2
235000007672 methylcobalamin Nutrition 0.000 title abstract 2
239000011585 methylcobalamin Substances 0.000 title abstract 2
JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 title abstract 2
229960005452 cobamamide Drugs 0.000 title 1
235000006279 cobamamide Nutrition 0.000 title 1
239000011789 cobamamide Substances 0.000 title 1
ZIHHMGTYZOSFRC-UWWAPWIJSA-M cobamamide Chemical compound C1(/[C@](C)(CCC(=O)NC[C@H](C)OP(O)(=O)OC2[C@H]([C@H](O[C@@H]2CO)N2C3=CC(C)=C(C)C=C3N=C2)O)[C@@H](CC(N)=O)[C@]2(N1[Co+]C[C@@H]1[C@H]([C@@H](O)[C@@H](O1)N1C3=NC=NC(N)=C3N=C1)O)[H])=C(C)\C([C@H](C/1(C)C)CCC(N)=O)=N\C\1=C/C([C@H]([C@@]\1(CC(N)=O)C)CCC(N)=O)=N/C/1=C(C)\C1=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O ZIHHMGTYZOSFRC-UWWAPWIJSA-M 0.000 title 1
239000007924 injection Substances 0.000 title 1
238000002347 injection Methods 0.000 title 1
239000007864 aqueous solution Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
238000000354 decomposition reaction Methods 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
235000000346 sugar Nutrition 0.000 abstract 1
150000008163 sugars Chemical class 0.000 abstract 1

Landscapes

Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP8161176A 1976-07-09 1976-07-09 Preparation of light-stable mecobalamin or cobamamide parenteral injections Granted JPS539312A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP8161176A JPS539312A (en)	1976-07-09	1976-07-09	Preparation of light-stable mecobalamin or cobamamide parenteral injections

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP8161176A JPS539312A (en)	1976-07-09	1976-07-09	Preparation of light-stable mecobalamin or cobamamide parenteral injections

Publications (2)

Publication Number	Publication Date
JPS539312A true JPS539312A (en)	1978-01-27
JPS5543446B2 JPS5543446B2 (2)	1980-11-06

Family

ID=13751105

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP8161176A Granted JPS539312A (en)	1976-07-09	1976-07-09	Preparation of light-stable mecobalamin or cobamamide parenteral injections

Country Status (1)

Country	Link
JP (1)	JPS539312A (2)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102895200A (zh) *	2012-11-02	2013-01-30	湖北人民制药有限公司	甲钴胺冻干组合物及其制备方法
CN104122363A (zh) *	2014-06-24	2014-10-29	杭州康恩贝制药有限公司	一种甲钴胺片有关物质的测定方法
CN105267161A (zh) *	2015-11-24	2016-01-27	河北智同生物制药有限公司	一种注射用腺苷钴胺冻干制剂组合物及其制备方法
JP2020196669A (ja) *	2019-05-31	2020-12-10	小林製薬株式会社	ビタミンｂ１２類の光安定化方法

1976
- 1976-07-09 JP JP8161176A patent/JPS539312A/ja active Granted

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102895200A (zh) *	2012-11-02	2013-01-30	湖北人民制药有限公司	甲钴胺冻干组合物及其制备方法
CN104122363A (zh) *	2014-06-24	2014-10-29	杭州康恩贝制药有限公司	一种甲钴胺片有关物质的测定方法
CN105267161A (zh) *	2015-11-24	2016-01-27	河北智同生物制药有限公司	一种注射用腺苷钴胺冻干制剂组合物及其制备方法
JP2020196669A (ja) *	2019-05-31	2020-12-10	小林製薬株式会社	ビタミンｂ１２類の光安定化方法

Also Published As

Publication number	Publication date
JPS5543446B2 (2)	1980-11-06

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