JPS54130596A - 2-azetidinone derivative and its preparation - Google Patents

2-azetidinone derivative and its preparation

Info

Publication number
JPS54130596A
JPS54130596A JP2415178A JP2415178A JPS54130596A JP S54130596 A JPS54130596 A JP S54130596A JP 2415178 A JP2415178 A JP 2415178A JP 2415178 A JP2415178 A JP 2415178A JP S54130596 A JPS54130596 A JP S54130596A
Authority
JP
Japan
Prior art keywords
azetidinone derivative
azabicyclo
aryl
formula
heterocyclic group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2415178A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Akira Sato
Yoshihiro Nakamizo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2415178A priority Critical patent/JPS54130596A/en
Publication of JPS54130596A publication Critical patent/JPS54130596A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:2-Azetidinone derivative of formula I [R1 is H, OH, (alkoxy- substituted) aralkyloxy, acyloxy, sulfonyloxy, amino, azido; R2 is H, alkyl, aralkyl; Y is aryl or heterocyclic group condensed to 3- and 4-positions of 1-azabicyclo [4,2,0]octene ring], and its pharmacologically acceptable salt.
EXAMPLE: (6S)-methyl-5,8-dioxo-benzo[C]-1-azabicyclo[4,2,0]octan-2-yl-carboxylate.
USE: Effective to suppress β-lactamase activity. Useful as a remedy for infectious diseases by applying together with penicillin, cephalosporin, etc.
PROCESS: Intra-molecular Friedel-Crafts reaction of 2-azetidinone derivative of formula II (A is OH, halogen; R3 is aryl, heterocyclic group) in the presence of a catalyst affords the compound I.
COPYRIGHT: (C)1979,JPO&Japio
JP2415178A 1978-03-03 1978-03-03 2-azetidinone derivative and its preparation Pending JPS54130596A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2415178A JPS54130596A (en) 1978-03-03 1978-03-03 2-azetidinone derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2415178A JPS54130596A (en) 1978-03-03 1978-03-03 2-azetidinone derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS54130596A true JPS54130596A (en) 1979-10-09

Family

ID=12130329

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2415178A Pending JPS54130596A (en) 1978-03-03 1978-03-03 2-azetidinone derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS54130596A (en)

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