JPS54145672A - N-substituted moranoline derivative - Google Patents

N-substituted moranoline derivative

Info

Publication number
JPS54145672A
JPS54145672A JP5360378A JP5360378A JPS54145672A JP S54145672 A JPS54145672 A JP S54145672A JP 5360378 A JP5360378 A JP 5360378A JP 5360378 A JP5360378 A JP 5360378A JP S54145672 A JPS54145672 A JP S54145672A
Authority
JP
Japan
Prior art keywords
formula
halide
aralkenyl
moranoline
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5360378A
Other languages
Japanese (ja)
Other versions
JPS5943947B2 (en
Inventor
Shingo Matsumura
Hiroshi Enomoto
Yoshiaki Aoyanagi
Yoshiaki Yoshikuni
Kohei Kura
Masahiro Yagi
Ichiro Shirahase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP53053603A priority Critical patent/JPS5943947B2/en
Priority to GB7909865A priority patent/GB2020278B/en
Priority to DE2915037A priority patent/DE2915037C3/en
Priority to FR7910559A priority patent/FR2424910A1/en
Priority to US06/033,839 priority patent/US4533668A/en
Priority to AT0324779A priority patent/AT371439B/en
Priority to DK178379A priority patent/DK151623C/en
Priority to IT48904/79A priority patent/IT1116820B/en
Priority to SE7903817A priority patent/SE436874B/en
Priority to NLAANVRAGE7903421,A priority patent/NL175820C/en
Priority to CH415879A priority patent/CH642629A5/en
Priority to BE0/194978A priority patent/BE876020A/en
Publication of JPS54145672A publication Critical patent/JPS54145672A/en
Priority to SE8402549A priority patent/SE451015B/en
Priority to SE8402550A priority patent/SE451016B/en
Priority to SE8402551A priority patent/SE451017B/en
Publication of JPS5943947B2 publication Critical patent/JPS5943947B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A N-substituted moranoline derivative of the formula (X is propylene or propenylene group).
EXAMPLE: N-Phenylpropylmoranoline.
USE: Preventives or remedies for diseases, e.g. diabetes mellitus, or its prodrome, hyperlipemia, arteriosclerosis, corpulence, cardiopathies such as myocardial infarction, gastroenteric disorder, such as gastritis, gastric ulcer, or duodenal ulcer, due to hyperglycemia, having hypoglycemic actions.
PROCESS: Moranoline is reacted with a reagent, e.g. an aralkyl halide, aralkenyl halide, or aralkylsulfonate, having an active aralkyl or aralkenyl group, in a polar solvent, e.g. water, an alcohol, DMSO, DMF, cellosolve, or glyme, in the presence of a deacidification agent at room temperature or above to give the compound of formula.
COPYRIGHT: (C)1979,JPO&Japio
JP53053603A 1978-05-03 1978-05-03 N-substituted moranoline derivatives Expired JPS5943947B2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP53053603A JPS5943947B2 (en) 1978-05-03 1978-05-03 N-substituted moranoline derivatives
GB7909865A GB2020278B (en) 1978-05-03 1979-03-21 Moranoline dervitives
DE2915037A DE2915037C3 (en) 1978-05-03 1979-04-12 New N-substituted moranoline derivatives
FR7910559A FR2424910A1 (en) 1978-05-03 1979-04-25 MORANOLINE N-SUBSTITUTES DERIVATIVES AND THEIR USE, IN PARTICULAR FOR THE TREATMENT OF HYPERGLYCEMIA
US06/033,839 US4533668A (en) 1978-05-03 1979-04-27 Antihyperglycemic moranoline derivatives
AT0324779A AT371439B (en) 1978-05-03 1979-04-30 METHOD FOR PRODUCING NEW N-SUBSTITUTED MORANOLINE DERIVATIVES AND THEIR SALTS
DK178379A DK151623C (en) 1978-05-03 1979-05-01 METHOD OF ANALOGUE FOR THE PREPARATION OF N-SUBSTITUTED MORANOLINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
IT48904/79A IT1116820B (en) 1978-05-03 1979-05-02 MORANOLINA DERIVATIVES WITH PHARMACOLOGICAL PROPERTIES
SE7903817A SE436874B (en) 1978-05-03 1979-05-02 N-SUBSTITUTED MORANOLINE DERIVATIVES
NLAANVRAGE7903421,A NL175820C (en) 1978-05-03 1979-05-02 N-SUBSTITUTED MORANOLINE DERIVATIVES, METHOD FOR PREPARING A MEDICINAL PRODUCT THEREFROM, AND MEDICINAL PRODUCT OBTAINED THEREFORE.
CH415879A CH642629A5 (en) 1978-05-03 1979-05-03 MORANOLINE DERIVATIVES SUBSTITUTED ON NITROGEN ATOM.
BE0/194978A BE876020A (en) 1978-05-03 1979-05-03 MORANOLINE DERIVATIVES
SE8402549A SE451015B (en) 1978-05-03 1984-05-11 SUBSTITUTED MORANOLINE DERIVATIVES
SE8402550A SE451016B (en) 1978-05-03 1984-05-11 N-SUBSTITUTED MORANOLINE DERIVATIVES
SE8402551A SE451017B (en) 1978-05-03 1984-05-11 CINNAMYLMORANOLIN DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53053603A JPS5943947B2 (en) 1978-05-03 1978-05-03 N-substituted moranoline derivatives

Publications (2)

Publication Number Publication Date
JPS54145672A true JPS54145672A (en) 1979-11-14
JPS5943947B2 JPS5943947B2 (en) 1984-10-25

Family

ID=12947448

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53053603A Expired JPS5943947B2 (en) 1978-05-03 1978-05-03 N-substituted moranoline derivatives

Country Status (3)

Country Link
JP (1) JPS5943947B2 (en)
AT (1) AT371439B (en)
BE (1) BE876020A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827701D0 (en) * 1987-12-09 1988-12-29 Nippon Shinyaku Co Ltd Thrombolytic &c compositions
WO1991003242A1 (en) * 1989-09-07 1991-03-21 Nippon Shinyaku Co., Ltd. Antiviral drug
US8975280B2 (en) * 2006-05-24 2015-03-10 The Chancellor, Masters And Scholars Of The University Of Oxford Deoxynojirimycin and D-arabinitol analogs and methods of using
CN118206479A (en) * 2022-12-16 2024-06-18 浙江大学 A 1-deoxynojirimycin derivative and its application

Also Published As

Publication number Publication date
BE876020A (en) 1979-09-03
JPS5943947B2 (en) 1984-10-25
ATA324779A (en) 1982-11-15
AT371439B (en) 1983-06-27

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