JPS5444681A - 5-fluororacil derivative - Google Patents

5-fluororacil derivative

Info

Publication number
JPS5444681A
JPS5444681A JP11037077A JP11037077A JPS5444681A JP S5444681 A JPS5444681 A JP S5444681A JP 11037077 A JP11037077 A JP 11037077A JP 11037077 A JP11037077 A JP 11037077A JP S5444681 A JPS5444681 A JP S5444681A
Authority
JP
Japan
Prior art keywords
formula
formulai
aryl
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11037077A
Other languages
Japanese (ja)
Inventor
Masakatsu Kaneko
Bunji Shimizu
Yorio Arakawa
Tsuneo Baba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP11037077A priority Critical patent/JPS5444681A/en
Priority to DK478177A priority patent/DK149818C/en
Priority to FR7732748A priority patent/FR2369296A1/en
Priority to DE19772748562 priority patent/DE2748562A1/en
Priority to CH1318477A priority patent/CH642974A5/en
Priority to NL7711911A priority patent/NL7711911A/en
Priority to CH2395/84A priority patent/CH650006A5/en
Priority to GB44960/77A priority patent/GB1541185A/en
Priority to US05/847,452 priority patent/US4248999A/en
Publication of JPS5444681A publication Critical patent/JPS5444681A/en
Priority to DK441680A priority patent/DK155331C/en
Priority to CH800481A priority patent/CH643272A5/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:5-Fluorouracil derivatives of formulaI[either R1 or R2 is formula II (R3 is H, alkyl, cycloalkyl, aryl) and the other is H].
EXAMPLE: 1-(5-Fluoro-1H-2-oxopyrimidiene-4-yl-β-D-galactopyranouronic acid.
USE: Low-toxicity carcinostatic agents.
PREPARATION: The condensation between 5-fluorouracil metal salt of formula III (R5 is hydroxyl group-protecting group that can be eliminated by reduction; M is metal) and a halogenogalactopyranouronic ester derivative of formula IV (R4 is alkyl, aryl; R6 is hydroxyl-protecting group) gives the compound of formula V, from which protecting groups are removed to afford the compound of formulaI.
COPYRIGHT: (C)1979,JPO&Japio
JP11037077A 1976-10-28 1977-09-13 5-fluororacil derivative Pending JPS5444681A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP11037077A JPS5444681A (en) 1977-09-13 1977-09-13 5-fluororacil derivative
DK478177A DK149818C (en) 1976-10-28 1977-10-27 ANALOGY PROCEDURE FOR PREPARING 5-FLUORURACIL DERIVATIVES
NL7711911A NL7711911A (en) 1976-10-28 1977-10-28 PROCESS FOR PREPARING 5-FLUORURACIL COMPOUNDS.
DE19772748562 DE2748562A1 (en) 1976-10-28 1977-10-28 5-FLUORURACIL DERIVATIVES AND PROCESS FOR THE PREPARATION
CH1318477A CH642974A5 (en) 1976-10-28 1977-10-28 Process for the preparation of 5-fluorouracil derivatives
FR7732748A FR2369296A1 (en) 1976-10-28 1977-10-28 5-FLUOROURACIL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
CH2395/84A CH650006A5 (en) 1976-10-28 1977-10-28 Process for the preparation of 5-fluorouracil derivatives
GB44960/77A GB1541185A (en) 1976-10-28 1977-10-28 5-fluorouracil derivatives and their preparation
US05/847,452 US4248999A (en) 1976-10-28 1977-10-31 5-Fluorouracil derivatives and process for preparing thereof
DK441680A DK155331C (en) 1976-10-28 1980-10-17 5-FLUORURACIL DERIVATIVES OR ACID ADDITION SALTS THEREOF USED AS INTERMEDIATES IN THE PREPARATION OF ANTITUMORALLY ACTIVE 5-FLOURURACIL COMPOUNDS
CH800481A CH643272A5 (en) 1976-10-28 1981-12-15 Process for the preparation of 5-fluorouracil derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11037077A JPS5444681A (en) 1977-09-13 1977-09-13 5-fluororacil derivative

Publications (1)

Publication Number Publication Date
JPS5444681A true JPS5444681A (en) 1979-04-09

Family

ID=14534064

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11037077A Pending JPS5444681A (en) 1976-10-28 1977-09-13 5-fluororacil derivative

Country Status (1)

Country Link
JP (1) JPS5444681A (en)

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