JPS5452059A - Synthesis of tobramycin - Google Patents

Synthesis of tobramycin

Info

Publication number
JPS5452059A
JPS5452059A JP11515277A JP11515277A JPS5452059A JP S5452059 A JPS5452059 A JP S5452059A JP 11515277 A JP11515277 A JP 11515277A JP 11515277 A JP11515277 A JP 11515277A JP S5452059 A JPS5452059 A JP S5452059A
Authority
JP
Japan
Prior art keywords
group
ring
derivative
amino group
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11515277A
Other languages
Japanese (ja)
Inventor
Takashi Yamaguchi
Isahiro Torii
Toshito Mori
Hamao Umezawa
Sumio Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Kowa Co Ltd
Original Assignee
Microbial Chemistry Research Foundation
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation, Kowa Co Ltd filed Critical Microbial Chemistry Research Foundation
Priority to JP11515277A priority Critical patent/JPS5452059A/en
Publication of JPS5452059A publication Critical patent/JPS5452059A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)

Abstract

PURPOSE: To prepare the title compound by condensing a lividamine derivative with a hexopyranose derivative, converting the sulfonyloxy group to amino group, opening the ring to a dialdehyde, closing the ring with nitromethane to obtain a diol, and reducing the nitro group to the amino group.
CONSTITUTION: Tobramycin VI is prepared by (1) condensing a lividamine derivative I [R1 is -OSO2R2 (R2 is alkyl, aralkyl, aryl); Y' is an OH-protecting group; Z is an amino-protecting grup]with hexopyranose or pentofuranose derivative II (Y is an OH-protecting group; X is halonen, A is III or IV) to obtain the compound V, (2) converting the 6'-position to amino group through azide group, (3) opening the ring by treating with periodic acid (aslt) to obtain a dialdehyde compound, (4) closing the ring by reacting nitromethane to obtain a diol-containing ring, and finally (5) reducing the nitro group to amino group
COPYRIGHT: (C)1979,JPO&Japio
JP11515277A 1977-09-27 1977-09-27 Synthesis of tobramycin Pending JPS5452059A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11515277A JPS5452059A (en) 1977-09-27 1977-09-27 Synthesis of tobramycin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11515277A JPS5452059A (en) 1977-09-27 1977-09-27 Synthesis of tobramycin

Publications (1)

Publication Number Publication Date
JPS5452059A true JPS5452059A (en) 1979-04-24

Family

ID=14655597

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11515277A Pending JPS5452059A (en) 1977-09-27 1977-09-27 Synthesis of tobramycin

Country Status (1)

Country Link
JP (1) JPS5452059A (en)

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