JPS5455562A - Lactam compound - Google Patents
Lactam compoundInfo
- Publication number
- JPS5455562A JPS5455562A JP12224977A JP12224977A JPS5455562A JP S5455562 A JPS5455562 A JP S5455562A JP 12224977 A JP12224977 A JP 12224977A JP 12224977 A JP12224977 A JP 12224977A JP S5455562 A JPS5455562 A JP S5455562A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- reduction
- alkoxycarbonyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Lactam compound Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- 206010021118 Hypotonia Diseases 0.000 abstract 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 abstract 1
- 239000012346 acetyl chloride Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 230000036640 muscle relaxation Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Lactam compounds of formula I (R1, R2 are H, acyl, alkoxycarbonyl; R3 is H, alkyl, phenyl that may be substituted; n is 1, 2).
EXAMPLE: 4-Diphenylmethyl-2-pyrrolidone.
USE: Antianxiety agent; they have extremely reduced side actions such as hypnosis and muscle relaxation activities and are observed to have antineuropasmolytic action.
PREPARATION: Cylization of a compound of formula III obained by the reduction of a compound of formula II in the presence of a mineral acid or the reduction of a compound of formula II under neutral or basic conditions with subsequent reaction of the resultant compound of formula I in which R1 is H with a reactive derivative of acid such as acetyl chloride or an alkoxycarbonyl halide forms a compound of formula I in which R1 is other than H
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12224977A JPS5455562A (en) | 1977-10-11 | 1977-10-11 | Lactam compound |
| AU40242/78A AU518986B2 (en) | 1977-10-11 | 1978-09-27 | Lactams |
| DK439878A DK439878A (en) | 1977-10-11 | 1978-10-04 | PROCEDURE FOR PREPARING LACTAM COMPOUNDS |
| CA312,844A CA1102338A (en) | 1977-10-11 | 1978-10-06 | Lactam compounds |
| EP78101094A EP0001601B1 (en) | 1977-10-11 | 1978-10-07 | Lactam compounds and methods for their preparation |
| DE7878101094T DE2861210D1 (en) | 1977-10-11 | 1978-10-07 | Lactam compounds and methods for their preparation |
| IT28617/78A IT1099358B (en) | 1977-10-11 | 1978-10-10 | ANSIOLYTIC ACTION LACTAMIC COMPOUNDS |
| NO783420A NO150041C (en) | 1977-10-11 | 1978-10-10 | ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE LACTAM COMPOUNDS |
| US05/950,524 US4198514A (en) | 1977-10-11 | 1978-10-11 | Lactam compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12224977A JPS5455562A (en) | 1977-10-11 | 1977-10-11 | Lactam compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5455562A true JPS5455562A (en) | 1979-05-02 |
Family
ID=14831277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12224977A Pending JPS5455562A (en) | 1977-10-11 | 1977-10-11 | Lactam compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5455562A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
-
1977
- 1977-10-11 JP JP12224977A patent/JPS5455562A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6972341B2 (en) | 2001-06-11 | 2005-12-06 | Xeno Port, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US7423169B2 (en) | 2001-06-11 | 2008-09-09 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
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