JPS5476552A - Production of prostaglandin analog - Google Patents
Production of prostaglandin analogInfo
- Publication number
- JPS5476552A JPS5476552A JP14228377A JP14228377A JPS5476552A JP S5476552 A JPS5476552 A JP S5476552A JP 14228377 A JP14228377 A JP 14228377A JP 14228377 A JP14228377 A JP 14228377A JP S5476552 A JPS5476552 A JP S5476552A
- Authority
- JP
- Japan
- Prior art keywords
- vinylene
- reagent
- recovered
- compound
- ethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 2
- 239000005977 Ethylene Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- OGHBATFHNDZKSO-UHFFFAOYSA-N propan-2-olate Chemical compound CC(C)[O-] OGHBATFHNDZKSO-UHFFFAOYSA-N 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: The oxo group in 15-position of prostanic acid derivative is reduced with diisobornyloxyaluminum isopropoxide to produce in one setp title compound used as a medicine in high selectively further under conditions where the reagent can be recovered.
CONSTITUTION: In the reduction of the oxo group in 15-position of the compound of formula I (X is ethylene, cis-vinylene; Y is ethylene or transvinylene; Z is trans- vinylene; R1 is 1-12C alkyl; R2 is H or OH-protecting group; R3 is single bond or others; R4 is H, 1-8C alkyl), diisobornyloxy-aluminum isopropoxide is employed to yield in high selectivity the compound of formula II that is used for producing prostaglandin analogs or their intermediates. The reagent can be recovered and reused according to the present invention.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14228377A JPS5476552A (en) | 1977-11-29 | 1977-11-29 | Production of prostaglandin analog |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14228377A JPS5476552A (en) | 1977-11-29 | 1977-11-29 | Production of prostaglandin analog |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5476552A true JPS5476552A (en) | 1979-06-19 |
Family
ID=15311758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14228377A Pending JPS5476552A (en) | 1977-11-29 | 1977-11-29 | Production of prostaglandin analog |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5476552A (en) |
-
1977
- 1977-11-29 JP JP14228377A patent/JPS5476552A/en active Pending
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