JPS5490171A - 5-cyano-1-methylpyrrole-2-acetic acid and its preparation - Google Patents
5-cyano-1-methylpyrrole-2-acetic acid and its preparationInfo
- Publication number
- JPS5490171A JPS5490171A JP14658177A JP14658177A JPS5490171A JP S5490171 A JPS5490171 A JP S5490171A JP 14658177 A JP14658177 A JP 14658177A JP 14658177 A JP14658177 A JP 14658177A JP S5490171 A JPS5490171 A JP S5490171A
- Authority
- JP
- Japan
- Prior art keywords
- acetic acid
- methylpyrrole
- methyl
- compound
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- APMOBEWQZBWHBO-UHFFFAOYSA-N 2-(5-cyano-1-methylpyrrol-2-yl)acetic acid Chemical compound CN1C(CC(O)=O)=CC=C1C#N APMOBEWQZBWHBO-UHFFFAOYSA-N 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- OXHNLMTVIGZXSG-UHFFFAOYSA-N 1-Methylpyrrole Chemical compound CN1C=CC=C1 OXHNLMTVIGZXSG-UHFFFAOYSA-N 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14658177A JPS5490171A (en) | 1977-12-08 | 1977-12-08 | 5-cyano-1-methylpyrrole-2-acetic acid and its preparation |
| SE7811704A SE435278B (sv) | 1977-12-08 | 1978-11-13 | 5-cyano-1-legre(c?711?71-?714)alkyl-pyrrol-2-ettiksyra, framstellning derav och anvendningen som mellanprodukt vid framstellning av terapeutiskt verksamma pyrrolderivat |
| US05/963,673 US4238396A (en) | 1977-12-08 | 1978-11-27 | 1-Hydrocarbyl-pyrrole-2-acetic acid derivatives and their production |
| GB7847086A GB2014131B (en) | 1977-12-08 | 1978-12-04 | 1-hydrocarbylpyrrole derivatives |
| ZA786818A ZA786818B (en) | 1977-12-08 | 1978-12-05 | 1-hydrocarbylpyrrole derivatives |
| PH21894A PH15394A (en) | 1977-12-08 | 1978-12-06 | Production of 1 hydrocarbyl pyrrole-2-acetic acids derivatives |
| ES475807A ES475807A1 (es) | 1977-12-08 | 1978-12-07 | Un procedimiento para preparar acidos 5-acil-1-hidrocarbil- pirrol-2-acetico. |
| DK553378A DK553378A (da) | 1977-12-08 | 1978-12-07 | Fremgangsmaade til fremstilling af 1-hydrocarbylpyrrol-2-eddikesyrederivater |
| IT52240/78A IT1157750B (it) | 1977-12-08 | 1978-12-07 | Procedimento per la preparazione di derivati di acido 1-idrocarbilpirrolo-2-acetico e prodotto ottenuto |
| CH1248078A CH644103A5 (de) | 1977-12-08 | 1978-12-07 | In 1-stellung durch einen kohlenwasserstoffrest substituierte 5-cyano-pyrrolyl-essigsaeuren, ihre herstellung und verwendung zur herstellung entsprechender 5-acyl-verbindungen. |
| BE192188A BE872594A (fr) | 1977-12-08 | 1978-12-07 | Derives d'acides 1-hydrocarbyl-pyrrole-2-acetiques et leur procede de production |
| DE2852975A DE2852975C2 (de) | 1977-12-08 | 1978-12-07 | 5-Cyano-1-alkylpyrrol-2-essigsäure-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| AU42313/78A AU529229B2 (en) | 1977-12-08 | 1978-12-07 | 1-hydrocarbylpyrrole derivatives x |
| LU80620A LU80620A1 (de) | 1977-12-08 | 1978-12-07 | 1-hydrocarbylpyrrol-2-essigsaeure-derivate und verfahren zu ihrer herstellung |
| FI783768A FI66848C (fi) | 1977-12-08 | 1978-12-07 | Foerfarande foer framstaellning av 1-alkylpyrrol-2-aettiksyraderivat den i foerfarandet anvaenda mellanprodukten och dess framstaellning |
| IE2419/78A IE47793B1 (en) | 1977-12-08 | 1978-12-07 | 1-hydrocarbylpyrrole derivatives |
| FR7834471A FR2411180A1 (fr) | 1977-12-08 | 1978-12-07 | Procede de preparation de 1-hydrocarbyl-2-(2',2',2'-trihalogeno-1'-hydroxyethyl)pyrroles |
| CA000317552A CA1121364A (fr) | 1977-12-08 | 1978-12-07 | Procedes d'obtention de derives des acides 1 - hydrocarbylpyrrole-2-acetique |
| NL7811940A NL7811940A (nl) | 1977-12-08 | 1978-12-07 | Werkwijze ter bereiding van 1-hydrocarbylpyrrool-2-azijnzuurderivaten. |
| PCT/JP1978/000044 WO1979000358A1 (fr) | 1977-12-08 | 1978-12-08 | Acide 5-cyano-1-methylpyrol-2-acetique et procede de preparation |
| FR7909463A FR2414040A1 (fr) | 1977-12-08 | 1979-04-13 | Acides 5-cyano-1-hydrocarbylpyrrole-2-acetiques leur preparation et leur application a la production d'acides 5-acyles correspondants |
| PH23259A PH17068A (en) | 1977-12-08 | 1979-11-08 | 5-cyano-1-methylpyrrole 2-acetic acid and process of preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14658177A JPS5490171A (en) | 1977-12-08 | 1977-12-08 | 5-cyano-1-methylpyrrole-2-acetic acid and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5490171A true JPS5490171A (en) | 1979-07-17 |
| JPS5512900B2 JPS5512900B2 (fr) | 1980-04-04 |
Family
ID=15410926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14658177A Granted JPS5490171A (en) | 1977-12-08 | 1977-12-08 | 5-cyano-1-methylpyrrole-2-acetic acid and its preparation |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5490171A (fr) |
| BE (1) | BE872594A (fr) |
| WO (1) | WO1979000358A1 (fr) |
| ZA (1) | ZA786818B (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55149252A (en) * | 1979-04-09 | 1980-11-20 | Ethyl Corp | Manufacture of 2*2*22trichloroo11*nn methylpyrrolee2**ethanol and its acidic solution |
| JPS5625156A (en) * | 1979-05-29 | 1981-03-10 | Ethyl Corp | Synthesization of 55cyanoo11hydrocarbylpyrrolee 22acetic acid |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2519555A1 (fr) * | 1982-01-11 | 1983-07-18 | Rhone Poulenc Sa | Appareillage et procede de plasmapherese alternative avec appareil a membrane |
| FR2548907B1 (fr) * | 1983-07-13 | 1985-11-08 | Rhone Poulenc Sa | Procede de plasmapherese et appareillage utilisable notamment pour ce procede |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3957818A (en) * | 1972-11-24 | 1976-05-18 | Mcneil Laboratories, Incorporated | Preparation of pyrrole-2-acetic acid derivatives |
-
1977
- 1977-12-08 JP JP14658177A patent/JPS5490171A/ja active Granted
-
1978
- 1978-12-05 ZA ZA786818A patent/ZA786818B/xx unknown
- 1978-12-07 BE BE192188A patent/BE872594A/fr not_active IP Right Cessation
- 1978-12-08 WO PCT/JP1978/000044 patent/WO1979000358A1/fr not_active Ceased
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55149252A (en) * | 1979-04-09 | 1980-11-20 | Ethyl Corp | Manufacture of 2*2*22trichloroo11*nn methylpyrrolee2**ethanol and its acidic solution |
| JPS5625156A (en) * | 1979-05-29 | 1981-03-10 | Ethyl Corp | Synthesization of 55cyanoo11hydrocarbylpyrrolee 22acetic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| BE872594A (fr) | 1979-06-07 |
| JPS5512900B2 (fr) | 1980-04-04 |
| ZA786818B (en) | 1980-07-30 |
| WO1979000358A1 (fr) | 1979-06-28 |
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