JPS5490184A - Preparation of 5-fluoro-orotic acid - Google Patents
Preparation of 5-fluoro-orotic acidInfo
- Publication number
- JPS5490184A JPS5490184A JP15667777A JP15667777A JPS5490184A JP S5490184 A JPS5490184 A JP S5490184A JP 15667777 A JP15667777 A JP 15667777A JP 15667777 A JP15667777 A JP 15667777A JP S5490184 A JPS5490184 A JP S5490184A
- Authority
- JP
- Japan
- Prior art keywords
- formic acid
- orotic acid
- fluorine gas
- fluoro
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the title compound useful as a raw material for oncostatic drugs with little discoloration at high selectivity in high yield and at a high reaction rate industrially advantageously, by reacting orotic acid with fluorine gas in inexpensive and available hydrous formic acid medium.
CONSTITUTION: Orotic acid is reacted with fluorine gas diluted with an inert gas, e.g. nitrogen, in hydrous formic acid medium at 0W60°C, particularly at 5W40°C. The formic acid is then removed to give an adduct of formula I, which is dissolved in water and heated at 90°C or above, or directly heated at 100W160°C to form 5-fluoro orotic acid of formula II. Preferably, the amount of water is 50 parts by wt. or less per 100 parts by wt. of formic acid, and the fluorine gas is diluted 1:1W 10 with the inert gas.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15667777A JPS5490184A (en) | 1977-12-27 | 1977-12-27 | Preparation of 5-fluoro-orotic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15667777A JPS5490184A (en) | 1977-12-27 | 1977-12-27 | Preparation of 5-fluoro-orotic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5490184A true JPS5490184A (en) | 1979-07-17 |
| JPS617196B2 JPS617196B2 (en) | 1986-03-04 |
Family
ID=15632895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15667777A Granted JPS5490184A (en) | 1977-12-27 | 1977-12-27 | Preparation of 5-fluoro-orotic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5490184A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01135892U (en) * | 1988-03-10 | 1989-09-18 |
-
1977
- 1977-12-27 JP JP15667777A patent/JPS5490184A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS617196B2 (en) | 1986-03-04 |
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