JPS5495580A - Isocarbostyril derivative - Google Patents

Isocarbostyril derivative

Info

Publication number
JPS5495580A
JPS5495580A JP19678A JP19678A JPS5495580A JP S5495580 A JPS5495580 A JP S5495580A JP 19678 A JP19678 A JP 19678A JP 19678 A JP19678 A JP 19678A JP S5495580 A JPS5495580 A JP S5495580A
Authority
JP
Japan
Prior art keywords
methyl
compound
isocarbostyril
formula
act
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP19678A
Other languages
Japanese (ja)
Other versions
JPS633859B2 (en
Inventor
Kiyoaki Niuchi
Atsuo Okubo
Akira Okabe
Seitaro Kajitani
Hajime Iizuka
Kengo Ootsuka
Ichiko Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP19678A priority Critical patent/JPS5495580A/en
Publication of JPS5495580A publication Critical patent/JPS5495580A/en
Publication of JPS633859B2 publication Critical patent/JPS633859B2/ja
Granted legal-status Critical Current

Links

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  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Isocarbostyril derivatives of formula I (R1 is H, methyl; R2 is H, OH, methoxy; R3, R4 are H, 1 - 6C alkyl, cyclohexyl, benzyl or incorporate to form a ring as morphline or N-methylpiperazine where cases that R1 is methyl, R2 is H, either R3 or R4 is H and the other is methyl are excluded) and their acid adducts.
EXAMPLE: 2-(3'-Cyclohexylamino-2'-hydroxy)propyl-5,6,7-trimethoxy-4-methyl- isocarbostyril.
USE: they have action of improving glycometabolism in liver, cardiac action, smooth muscle relaxation, bronchodilation, being useful for a variety of medicines, preferably hypotensor.
PREPARATION: A compound of formula III is made to act on a compound of formula II (R is H, Ro is H, mehoxy) and an amine is made to act on the product to prepare the objective compound.
COPYRIGHT: (C)1979,JPO&Japio
JP19678A 1978-01-06 1978-01-06 Isocarbostyril derivative Granted JPS5495580A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP19678A JPS5495580A (en) 1978-01-06 1978-01-06 Isocarbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19678A JPS5495580A (en) 1978-01-06 1978-01-06 Isocarbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5495580A true JPS5495580A (en) 1979-07-28
JPS633859B2 JPS633859B2 (en) 1988-01-26

Family

ID=11467230

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19678A Granted JPS5495580A (en) 1978-01-06 1978-01-06 Isocarbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5495580A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054979A1 (en) * 2002-12-18 2004-07-01 Takeda Pharmaceutical Company Limited Jnk inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054979A1 (en) * 2002-12-18 2004-07-01 Takeda Pharmaceutical Company Limited Jnk inhibitors

Also Published As

Publication number Publication date
JPS633859B2 (en) 1988-01-26

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