JPS55105656A - Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide - Google Patents

Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide

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Publication number
JPS55105656A
JPS55105656A JP1404079A JP1404079A JPS55105656A JP S55105656 A JPS55105656 A JP S55105656A JP 1404079 A JP1404079 A JP 1404079A JP 1404079 A JP1404079 A JP 1404079A JP S55105656 A JPS55105656 A JP S55105656A
Authority
JP
Japan
Prior art keywords
disubstituted
title compound
bromophenylacetamide
dichloroaniline
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1404079A
Other languages
Japanese (ja)
Inventor
Fujio Nohara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IKEDA MOHANDOU KK
Original Assignee
IKEDA MOHANDOU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IKEDA MOHANDOU KK filed Critical IKEDA MOHANDOU KK
Priority to JP1404079A priority Critical patent/JPS55105656A/en
Publication of JPS55105656A publication Critical patent/JPS55105656A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound useful as a raw material through an easy preparation of Diclofenac, a nonsteroid analgic antiphlogistica, by reacting N,N- disubstituted-O-bromophenylacetamide derivative with 2,6-dichloroaniline in the presence of a cupric catalyst.
CONSTITUTION: An N,N-disubstituted-O-bromophenylacetamide derivative shown by the formula I (R1 and R2 are lower alkyl; R1 and R2 link together with N and/or O to form a heterocyclic ring) is reacted with 2,6-dichloroaniline in the presence of a cupric catalyst, e.g., CuBr2 [and, if necessary, an deoxidizer (e.g., an alkali metal carbonate, etc.] and a cocatalyst of NaI in a solvent, e.g., chlorobenzene at a temperature not lower than 80°C to give the title compound shown by the formula II.
EFFECT: The title compound is obtained from low-priced raw materials in extremely few steps in high yields in all processes and the procedures are simple. The compound is very safe and has a good crystallizability.
COPYRIGHT: (C)1980,JPO&Japio
JP1404079A 1979-02-09 1979-02-09 Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide Pending JPS55105656A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1404079A JPS55105656A (en) 1979-02-09 1979-02-09 Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1404079A JPS55105656A (en) 1979-02-09 1979-02-09 Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide

Publications (1)

Publication Number Publication Date
JPS55105656A true JPS55105656A (en) 1980-08-13

Family

ID=11849995

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1404079A Pending JPS55105656A (en) 1979-02-09 1979-02-09 Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide

Country Status (1)

Country Link
JP (1) JPS55105656A (en)

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