JPS55111489A - Penicillin derivative, its preparation, and antibacterial agent comprising it - Google Patents
Penicillin derivative, its preparation, and antibacterial agent comprising itInfo
- Publication number
- JPS55111489A JPS55111489A JP1718179A JP1718179A JPS55111489A JP S55111489 A JPS55111489 A JP S55111489A JP 1718179 A JP1718179 A JP 1718179A JP 1718179 A JP1718179 A JP 1718179A JP S55111489 A JPS55111489 A JP S55111489A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- salt
- gram
- antibacterial agent
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 150000002960 penicillins Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- -1 e.g. Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A penicillin derivative shown by the formula I (R1 is H or OH; R2WR5 are H, OH, alkyl, etc. with the exception that all of R2WR5 are H) and its nontoxic salt.
EXAMPLE: D(-)-α-(7-acetoxychromone-3-carbonylamino)benzylpericillin.
USE: An antibacterial agent. Effective against gram-positive and gram-negative and gram-negative bacteria, especially pseudomonas aeruginosa and low toxic.
PROCESS: A compound shwon by the formula II, its salt, or its hydrate, is reacted with a compound shown by the formula III or its reactive derivative to give a compound shown by the formula I or its salt. The reaction is carried out in an inert solvent, e.g., acetone, etc., and, if necessary, in the presence of a dehydrating and condensation agent, a base or a silylating agent.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1718179A JPS55111489A (en) | 1979-02-19 | 1979-02-19 | Penicillin derivative, its preparation, and antibacterial agent comprising it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1718179A JPS55111489A (en) | 1979-02-19 | 1979-02-19 | Penicillin derivative, its preparation, and antibacterial agent comprising it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55111489A true JPS55111489A (en) | 1980-08-28 |
| JPS6233235B2 JPS6233235B2 (en) | 1987-07-20 |
Family
ID=11936769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1718179A Granted JPS55111489A (en) | 1979-02-19 | 1979-02-19 | Penicillin derivative, its preparation, and antibacterial agent comprising it |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55111489A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4892391A (en) * | 1972-03-15 | 1973-11-30 | ||
| JPS5412392A (en) * | 1977-06-28 | 1979-01-30 | Teijin Ltd | Novel penicillin derivative, medicine therefrom and its production |
| JPS54109995A (en) * | 1978-01-16 | 1979-08-29 | Sandoz Ag | Novel penicillins and cephalosporins and their manufacture and use |
-
1979
- 1979-02-19 JP JP1718179A patent/JPS55111489A/en active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4892391A (en) * | 1972-03-15 | 1973-11-30 | ||
| JPS5412392A (en) * | 1977-06-28 | 1979-01-30 | Teijin Ltd | Novel penicillin derivative, medicine therefrom and its production |
| JPS54109995A (en) * | 1978-01-16 | 1979-08-29 | Sandoz Ag | Novel penicillins and cephalosporins and their manufacture and use |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6233235B2 (en) | 1987-07-20 |
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