JPS5513216A - Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine - Google Patents
Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthineInfo
- Publication number
- JPS5513216A JPS5513216A JP8538278A JP8538278A JPS5513216A JP S5513216 A JPS5513216 A JP S5513216A JP 8538278 A JP8538278 A JP 8538278A JP 8538278 A JP8538278 A JP 8538278A JP S5513216 A JPS5513216 A JP S5513216A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- dimethylxanthine
- compound shown
- sulfonyloxypropyl
- acetoacetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 1-(3- sulfonyloxypropyl)-3,7-dimethylxanthine Chemical class 0.000 abstract 2
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 abstract 2
- GHGVDQNEKGZLPE-UHFFFAOYSA-N 1-(3-hydroxypropyl)-3,7-dimethylpurine-2,6-dione Chemical compound CN1C(=O)N(CCCO)C(=O)C2=C1N=CN2C GHGVDQNEKGZLPE-UHFFFAOYSA-N 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 229910005948 SO2Cl Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 230000010339 dilation Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1
Abstract
PURPOSE: To prepare the title compound for use as medicines having improved dilation action of blood vessels in high yield, by reacting a low-priced novel 1-(3- sulfonyloxypropyl)-3,7-dimethylxanthine with an acetoacetate.
CONSTITUTION: A 1-(3-sulfonyloxypropyl)-3,7-dimethylxanthine shown by the formula II (R is alkyl, aryl, aralkyl, which may hava a sybstituent group) is reacted with an acetoacetate, and the reaction product is subjected to ketonic decomposition to prepare the desired compound shown by the formula I. The novel compound shown by the formula II is obtained by reacting 1-(3-hydroxypropyl)-3,7-dimethylxanthine with a sulfonyl chloride shown by the formula R1SO2Cl. Sulfonic acid produced as by-products can be recovered and reused as a raw material of the compound shown by the formula II.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8538278A JPS5513216A (en) | 1978-07-13 | 1978-07-13 | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8538278A JPS5513216A (en) | 1978-07-13 | 1978-07-13 | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5513216A true JPS5513216A (en) | 1980-01-30 |
Family
ID=13857180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8538278A Pending JPS5513216A (en) | 1978-07-13 | 1978-07-13 | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5513216A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110627792A (en) * | 2019-10-18 | 2019-12-31 | 海南顿斯医药科技有限公司 | Pentoxifylline compound |
-
1978
- 1978-07-13 JP JP8538278A patent/JPS5513216A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110627792A (en) * | 2019-10-18 | 2019-12-31 | 海南顿斯医药科技有限公司 | Pentoxifylline compound |
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