JPS5515401A - 1-substituted-2-4-(1-oxo-2-isoindolinyl)phenyl-propyl alcohol and their preparation - Google Patents

1-substituted-2-4-(1-oxo-2-isoindolinyl)phenyl-propyl alcohol and their preparation

Info

Publication number
JPS5515401A
JPS5515401A JP8670478A JP8670478A JPS5515401A JP S5515401 A JPS5515401 A JP S5515401A JP 8670478 A JP8670478 A JP 8670478A JP 8670478 A JP8670478 A JP 8670478A JP S5515401 A JPS5515401 A JP S5515401A
Authority
JP
Japan
Prior art keywords
compound
formula
isoindolinyl
oxo
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8670478A
Other languages
Japanese (ja)
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Haruhide Ishimaru
Tsuneo Uryu
Toshihisa Nakamura
Keiko Shiroyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP8670478A priority Critical patent/JPS5515401A/en
Publication of JPS5515401A publication Critical patent/JPS5515401A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:The title compound of formula I (X=amide, acylamide, carboxyl, alkoxycarbonyl, nitrile; R=H, acyl, tosyl).
EXAMPLE: 2-Hydroxy-3-[4-(1-oxo-2-isoindolinyl)phenyl]butanamide.
USE: Excellent antiphlogistic analgesic agent.
PROCESS: A compound of formula II (X1=amide, carboxyl, alkoxycarbonyl) is hydrogenated to give a compound of formula III, which is then acylated or tosylated into a compound of formula I. A metal catalyst, e.g. Pt, Ni, etc., is used in the catalytic reduction. An acylating agent, e.g. acetyl chloride, or a tosylating agnet, e.g. tosyl chloride, is used in the acylatiob, etc. of the compound III.
COPYRIGHT: (C)1980,JPO&Japio
JP8670478A 1978-07-18 1978-07-18 1-substituted-2-4-(1-oxo-2-isoindolinyl)phenyl-propyl alcohol and their preparation Pending JPS5515401A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8670478A JPS5515401A (en) 1978-07-18 1978-07-18 1-substituted-2-4-(1-oxo-2-isoindolinyl)phenyl-propyl alcohol and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8670478A JPS5515401A (en) 1978-07-18 1978-07-18 1-substituted-2-4-(1-oxo-2-isoindolinyl)phenyl-propyl alcohol and their preparation

Publications (1)

Publication Number Publication Date
JPS5515401A true JPS5515401A (en) 1980-02-02

Family

ID=13894312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8670478A Pending JPS5515401A (en) 1978-07-18 1978-07-18 1-substituted-2-4-(1-oxo-2-isoindolinyl)phenyl-propyl alcohol and their preparation

Country Status (1)

Country Link
JP (1) JPS5515401A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5548260A (en) * 1992-05-06 1996-08-20 Mitsuba Electric Manufacturing Co., Ltd. Contact assembly for a magnetic switch

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5548260A (en) * 1992-05-06 1996-08-20 Mitsuba Electric Manufacturing Co., Ltd. Contact assembly for a magnetic switch

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