JPS5522631A - Readily absorbable nifedipine preparation - Google Patents
Readily absorbable nifedipine preparationInfo
- Publication number
- JPS5522631A JPS5522631A JP9538878A JP9538878A JPS5522631A JP S5522631 A JPS5522631 A JP S5522631A JP 9538878 A JP9538878 A JP 9538878A JP 9538878 A JP9538878 A JP 9538878A JP S5522631 A JPS5522631 A JP S5522631A
- Authority
- JP
- Japan
- Prior art keywords
- nifedipine
- preparation
- readily
- angina pectoris
- case
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title abstract 5
- 229960001597 nifedipine Drugs 0.000 title abstract 5
- 206010002383 Angina Pectoris Diseases 0.000 abstract 2
- 239000003218 coronary vasodilator agent Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: The title preparation having improved absorbability after oral administration, comprising Nifedipine having a coronary vasodilator action and specific two types of compounds.
CONSTITUTION: One part by wt. of Nifedipine useful as a drug for angina pectoris, having a coronary vasodilator action is incorporated with 5W60 parts by wt. of polyethylene glycol having a molecular weight of 200W6,000 and 1/1000W1/10 part by wt. of a polyoxyethylene sorbitan monooleate to give a readily absorbable Nifedipine preparation. Drugs must be administered and absorbed readily in the case of angina pectoris fits. The product can increase the level in the serum after administration 15W25 times that in the case of simple Nifedipine alone. The time required for reaching the maximum level in the blood can be shortened to 1hr.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9538878A JPS5522631A (en) | 1978-08-07 | 1978-08-07 | Readily absorbable nifedipine preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9538878A JPS5522631A (en) | 1978-08-07 | 1978-08-07 | Readily absorbable nifedipine preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5522631A true JPS5522631A (en) | 1980-02-18 |
| JPS6140647B2 JPS6140647B2 (en) | 1986-09-10 |
Family
ID=14136261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9538878A Granted JPS5522631A (en) | 1978-08-07 | 1978-08-07 | Readily absorbable nifedipine preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5522631A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58105913A (en) * | 1981-12-18 | 1983-06-24 | Nippon Chemiphar Co Ltd | Nifedipine soft capsule |
| WO1984003440A1 (en) * | 1981-09-14 | 1984-09-13 | Kanebo Ltd | Long-acting nifedipine preparation |
| JPS60105611A (en) * | 1983-11-14 | 1985-06-11 | Nippon Chemiphar Co Ltd | Soft capsule of nifedipine |
| JPS618A (en) * | 1984-06-09 | 1986-01-06 | Sawai Seiyaku Kk | Nifedipin-containing drug preparation |
| JPS61100528A (en) * | 1984-10-23 | 1986-05-19 | ドクトル レンチユレル アルツナイミツテル ゲ−エムベ−ハ− ウント コ− | Nifedipin-containing drug composition and manufacture |
| EP0278168A1 (en) * | 1986-12-12 | 1988-08-17 | Harris Pharmaceuticals Ltd | Nifedipine capsules |
| JPH0352886A (en) * | 1989-07-20 | 1991-03-07 | Nisshin Flour Milling Co Ltd | 1,4-dihydropyridine composition |
| WO2003094897A1 (en) | 2002-05-09 | 2003-11-20 | Chugai Seiyaku Kabushiki Kaisha | Photostabilized soft capsule |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4828621A (en) * | 1971-08-24 | 1973-04-16 |
-
1978
- 1978-08-07 JP JP9538878A patent/JPS5522631A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4828621A (en) * | 1971-08-24 | 1973-04-16 |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984003440A1 (en) * | 1981-09-14 | 1984-09-13 | Kanebo Ltd | Long-acting nifedipine preparation |
| JPS58105913A (en) * | 1981-12-18 | 1983-06-24 | Nippon Chemiphar Co Ltd | Nifedipine soft capsule |
| JPS60105611A (en) * | 1983-11-14 | 1985-06-11 | Nippon Chemiphar Co Ltd | Soft capsule of nifedipine |
| JPS618A (en) * | 1984-06-09 | 1986-01-06 | Sawai Seiyaku Kk | Nifedipin-containing drug preparation |
| JPS61100528A (en) * | 1984-10-23 | 1986-05-19 | ドクトル レンチユレル アルツナイミツテル ゲ−エムベ−ハ− ウント コ− | Nifedipin-containing drug composition and manufacture |
| EP0278168A1 (en) * | 1986-12-12 | 1988-08-17 | Harris Pharmaceuticals Ltd | Nifedipine capsules |
| JPH0352886A (en) * | 1989-07-20 | 1991-03-07 | Nisshin Flour Milling Co Ltd | 1,4-dihydropyridine composition |
| WO2003094897A1 (en) | 2002-05-09 | 2003-11-20 | Chugai Seiyaku Kabushiki Kaisha | Photostabilized soft capsule |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6140647B2 (en) | 1986-09-10 |
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