Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co LtdfiledCriticalGrelan Pharmaceutical Co Ltd
Priority to JP10068478ApriorityCriticalpatent/JPS5528902A/en
Publication of JPS5528902ApublicationCriticalpatent/JPS5528902A/en
PURPOSE: To obtain the title compound as an agent for circulatory system treating such as a treating agent for cerebral thrombosis sequela, etc. in one step and in high yield, by reacting a 1-halogenoalky1-3,7-dialkyl-xanthine with pentane-2,4-dione in the presence of a base.
CONSTITUTION: A 1-(halogenoalkyl)-3,7-dialkyl-xanthine of formula I (R is lower alkyl; X is halogen; n is 3 or 4) is reacted with pentane-2,4-dione in the presence of a base to produce a xanthine derivative of formula II (n is 4 or 5) [e.g. 1-(5-oxohexyl)-3,7-dimethyl xanthine]. 1-(3-Bromopropyl), 1-(3-iodopropyl)-3,7- dimethylxanthines, etc. may be cited as the raw material.
COPYRIGHT: (C)1980,JPO&Japio
JP10068478A1978-08-181978-08-18Preparation of xanthine derivative
PendingJPS5528902A
(en)
Process for producing new 2,6-dimethyl-4(pyrazolo square brackets open 1,5-a square brackets closed pyridin-3-ol)-1,4-dihydro-pyridine-3,5-dicarboxylic acid derivatives increasing the effect of antitumour agents, as well as pharmaceutics comprising the same