JPS5528952A - Racemization of optically active alpha-substituted arylacetic acid - Google Patents
Racemization of optically active alpha-substituted arylacetic acidInfo
- Publication number
- JPS5528952A JPS5528952A JP10232578A JP10232578A JPS5528952A JP S5528952 A JPS5528952 A JP S5528952A JP 10232578 A JP10232578 A JP 10232578A JP 10232578 A JP10232578 A JP 10232578A JP S5528952 A JPS5528952 A JP S5528952A
- Authority
- JP
- Japan
- Prior art keywords
- racemization
- optically active
- active alpha
- arylacetic acid
- substituted arylacetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title 1
- 230000006340 racemization Effects 0.000 title 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- LUZDYPLAQQGJEA-UHFFFAOYSA-N 2-Methoxynaphthalene Chemical compound C1=CC=CC2=CC(OC)=CC=C21 LUZDYPLAQQGJEA-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To recemize the title compound useful as a medicine, in high efficiency, by racemizing in the presence of a specific N-containing strong base.
CONSTITUTION: d-or l-2-(6-methoxy-2-naphthyl)propionic acid, or their mixture is treated with an N-containing strong base such as 1,5-diazabicyclo[5.4.0]undecene-5, 1,5-diazabicyclo[4.3.0]nonene-5, etc., in a polar solvent (e.g. DMF, ethyene glycol, etc.), pref. at 90W120°C, to afford the dl racemate. the compound I is prepared according to the reaction formulas, from 2-methoxynaphthalene II.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10232578A JPS5817450B2 (en) | 1978-08-24 | 1978-08-24 | Racemization method for optically active α-substituted aryl acetic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10232578A JPS5817450B2 (en) | 1978-08-24 | 1978-08-24 | Racemization method for optically active α-substituted aryl acetic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5528952A true JPS5528952A (en) | 1980-02-29 |
| JPS5817450B2 JPS5817450B2 (en) | 1983-04-07 |
Family
ID=14324392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10232578A Expired JPS5817450B2 (en) | 1978-08-24 | 1978-08-24 | Racemization method for optically active α-substituted aryl acetic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5817450B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02292235A (en) * | 1989-05-08 | 1990-12-03 | Sumitomo Chem Co Ltd | Racemization of optically active alpha-isopropyl-p-chlorophenylacetic acid or its diastereoisomer salt |
-
1978
- 1978-08-24 JP JP10232578A patent/JPS5817450B2/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02292235A (en) * | 1989-05-08 | 1990-12-03 | Sumitomo Chem Co Ltd | Racemization of optically active alpha-isopropyl-p-chlorophenylacetic acid or its diastereoisomer salt |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5817450B2 (en) | 1983-04-07 |
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