JPS5533433A - Production of 6-nucleoside derivative - Google Patents
Production of 6-nucleoside derivativeInfo
- Publication number
- JPS5533433A JPS5533433A JP10625478A JP10625478A JPS5533433A JP S5533433 A JPS5533433 A JP S5533433A JP 10625478 A JP10625478 A JP 10625478A JP 10625478 A JP10625478 A JP 10625478A JP S5533433 A JPS5533433 A JP S5533433A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- chloropurine
- ribofuranosyl
- effected
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- XHRJGHCQQPETRH-KQYNXXCUSA-N (2r,3r,4s,5r)-2-(6-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(Cl)=C2N=C1 XHRJGHCQQPETRH-KQYNXXCUSA-N 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 2
- 230000002622 anti-tumorigenesis Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: The reaction of a specific 9-β-D-ribofuranosyl-6-chloropurine with a carboxylic ester is effected in the presence of a base to produce readily title compound useful as synthetic intermediate of antitumorigenic agent.
CONSTITUTION: The reaction between 9-β-D-ribofuranosyl-6-chloropurine of formula I (Y, Z are H, protecting groups) and a carboxylic ester of formula II (R1 is alkyl, OR2; R2 is alkyl, aralkyl) is effected in a solvent of dimethylsulfoxide, hexamethyl phosphoroamide in the presence of a base as sodium hydroxide, n-butyl lithium at a temperature of room temperature to refluxing one, preferably under anhydrous conditions, to produce of 2-(9-β-D-ribofuranosylpurine-6-yl) acetate or its derivative of formula III (R3 is H, COOR2).
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10625478A JPS5533433A (en) | 1978-09-01 | 1978-09-01 | Production of 6-nucleoside derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10625478A JPS5533433A (en) | 1978-09-01 | 1978-09-01 | Production of 6-nucleoside derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5533433A true JPS5533433A (en) | 1980-03-08 |
| JPS5728719B2 JPS5728719B2 (en) | 1982-06-18 |
Family
ID=14428958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10625478A Granted JPS5533433A (en) | 1978-09-01 | 1978-09-01 | Production of 6-nucleoside derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5533433A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5758664A (en) * | 1980-09-24 | 1982-04-08 | Otsuka Pharmaceut Co Ltd | Alkanoic acid derivative |
| JP2008140727A (en) * | 2006-12-05 | 2008-06-19 | Yazaki Corp | Wiring tool for LED, LED pressure welding unit, and wiring unit with LED |
-
1978
- 1978-09-01 JP JP10625478A patent/JPS5533433A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5758664A (en) * | 1980-09-24 | 1982-04-08 | Otsuka Pharmaceut Co Ltd | Alkanoic acid derivative |
| JP2008140727A (en) * | 2006-12-05 | 2008-06-19 | Yazaki Corp | Wiring tool for LED, LED pressure welding unit, and wiring unit with LED |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5728719B2 (en) | 1982-06-18 |
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