JPS5533499A - N2-arylsulfonyl-l-arginineamide and its pharmaceutically acceptable salt - Google Patents

N2-arylsulfonyl-l-arginineamide and its pharmaceutically acceptable salt

Info

Publication number
JPS5533499A
JPS5533499A JP11091179A JP11091179A JPS5533499A JP S5533499 A JPS5533499 A JP S5533499A JP 11091179 A JP11091179 A JP 11091179A JP 11091179 A JP11091179 A JP 11091179A JP S5533499 A JPS5533499 A JP S5533499A
Authority
JP
Japan
Prior art keywords
formula
compound
alkyl group
arginineamide
arylsulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11091179A
Other languages
Japanese (ja)
Other versions
JPH0135000B2 (en
Inventor
Akiyoshi Okamoto
Ryoji Kikumoto
Yoshikuni Tamao
Kazuo Okubo
Toru Tezuka
Shinji Tonomura
Akiko Hijikata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25471841&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5533499(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/938,711 external-priority patent/US4201863A/en
Application filed by Mitsubishi Chemical Industries Ltd filed Critical Mitsubishi Chemical Industries Ltd
Publication of JPS5533499A publication Critical patent/JPS5533499A/en
Publication of JPH0135000B2 publication Critical patent/JPH0135000B2/ja
Granted legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01Q—ANTENNAS, i.e. RADIO AERIALS
    • H01Q1/00—Details of, or arrangements associated with, antennas
    • H01Q1/08—Means for collapsing antennas or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A compound of formula I: [R is formula III (R1 is H or 1-5C alkyl group); Ar is 1,2,3,4-tetrahydro-8-quinolyl group which may be substituted by at least one 1-5C alkyl group], and its pharmacentically acceptable salts. EXAMPLE:1-[ N<2>-( 1, 2, 3, 4-Tetrahydro-8-quinolinesulfonyl)-L-arginyl ]-4-methyl-2-piperidinecarboxylic acid. USE:Antithrombins and blood platelet antiagglutinating agents, having a selective inhibitory action on thrombin with low toxicity, useful as a reagent for determination of blood thrombin, or a remedy and preventive for thrombosis. PROCESS:A compound of formula X (R2 is H, alkyl group, etc.; Q is 8-quinolyl group, etc.), obtained from a compound of formula II, is reduced, and, if necessary, subjected to hydrogenolysis or hydrolysis to give the compound of formula I.
JP11091179A 1978-08-31 1979-08-30 N2-arylsulfonyl-l-arginineamide and its pharmaceutically acceptable salt Granted JPS5533499A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/938,711 US4201863A (en) 1974-11-08 1978-08-31 N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof

Publications (2)

Publication Number Publication Date
JPS5533499A true JPS5533499A (en) 1980-03-08
JPH0135000B2 JPH0135000B2 (en) 1989-07-21

Family

ID=25471841

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11091179A Granted JPS5533499A (en) 1978-08-31 1979-08-30 N2-arylsulfonyl-l-arginineamide and its pharmaceutically acceptable salt

Country Status (3)

Country Link
JP (1) JPS5533499A (en)
SU (1) SU1042615A3 (en)
ZA (1) ZA794581B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5782314A (en) * 1980-11-13 1982-05-22 Mitsubishi Chem Ind Ltd Carcinostatic agent
JP2000053571A (en) * 1998-08-07 2000-02-22 Mitsubishi Chemicals Corp Prevention and treatment of brain damage
JP2007332093A (en) * 2006-06-16 2007-12-27 Apro Life Science Institute Inc Protein refolding additive and protein regeneration method using the same
JP2011516519A (en) * 2008-04-07 2011-05-26 ランドベック ファルマチェウティカルズ イタリー ソシエタ ペル アチオニ Polymorph of argatroban monohydrate and its synthesis
JP2017186350A (en) * 2011-04-04 2017-10-12 ルンドベック ファーマシューティカルズ イタリー ソシエタ ペル アチオニ Manufacturing method of process intermediate for synthesizing argatroban monohydrate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5297934A (en) * 1975-12-09 1977-08-17 Mitsubishi Chem Ind Ltd N#-arylsulfonyl-l-argininamides and their salts acceptable as medicine s
DE2801478A1 (en) * 1977-01-19 1978-07-20 Mitsubishi Chem Ind N HIGH 2 -ARYLSULFONYL-L-ARGININAMIDE, THE METHOD OF MANUFACTURING IT AND THE MEDICINAL PRODUCTS CONTAINING IT

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5297934A (en) * 1975-12-09 1977-08-17 Mitsubishi Chem Ind Ltd N#-arylsulfonyl-l-argininamides and their salts acceptable as medicine s
DE2801478A1 (en) * 1977-01-19 1978-07-20 Mitsubishi Chem Ind N HIGH 2 -ARYLSULFONYL-L-ARGININAMIDE, THE METHOD OF MANUFACTURING IT AND THE MEDICINAL PRODUCTS CONTAINING IT

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5782314A (en) * 1980-11-13 1982-05-22 Mitsubishi Chem Ind Ltd Carcinostatic agent
JP2000053571A (en) * 1998-08-07 2000-02-22 Mitsubishi Chemicals Corp Prevention and treatment of brain damage
JP2007332093A (en) * 2006-06-16 2007-12-27 Apro Life Science Institute Inc Protein refolding additive and protein regeneration method using the same
JP2011516519A (en) * 2008-04-07 2011-05-26 ランドベック ファルマチェウティカルズ イタリー ソシエタ ペル アチオニ Polymorph of argatroban monohydrate and its synthesis
JP2017186350A (en) * 2011-04-04 2017-10-12 ルンドベック ファーマシューティカルズ イタリー ソシエタ ペル アチオニ Manufacturing method of process intermediate for synthesizing argatroban monohydrate
US10385020B2 (en) 2011-04-04 2019-08-20 Lundbeck Pharmaceuticals Italy S.P.A. Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate

Also Published As

Publication number Publication date
ZA794581B (en) 1981-04-29
SU1042615A3 (en) 1983-09-15
JPH0135000B2 (en) 1989-07-21

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term