JPS5538366A - Intermediate for synthesizing novel azacycloalkane compound - Google Patents

Intermediate for synthesizing novel azacycloalkane compound

Info

Publication number
JPS5538366A
JPS5538366A JP15404878A JP15404878A JPS5538366A JP S5538366 A JPS5538366 A JP S5538366A JP 15404878 A JP15404878 A JP 15404878A JP 15404878 A JP15404878 A JP 15404878A JP S5538366 A JPS5538366 A JP S5538366A
Authority
JP
Japan
Prior art keywords
synthesizing novel
compound
azacycloalkane compound
novel azacycloalkane
synthesizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15404878A
Other languages
English (en)
Inventor
Henrii Oruzaisu Toomasu
Aamon Haabaato Chiyaaruzu
Rosu Jiyonson Maikeru
Shiyaaman Merubin Jiy Roorensu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Original Assignee
PFIZER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER filed Critical PFIZER
Publication of JPS5538366A publication Critical patent/JPS5538366A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
JP15404878A 1977-09-13 1978-12-13 Intermediate for synthesizing novel azacycloalkane compound Pending JPS5538366A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/832,869 US4147872A (en) 1977-09-13 1977-09-13 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives thereof as analgesic agents and intermediates therefor

Publications (1)

Publication Number Publication Date
JPS5538366A true JPS5538366A (en) 1980-03-17

Family

ID=25262819

Family Applications (5)

Application Number Title Priority Date Filing Date
JP53112171A Expired JPS5935397B2 (ja) 1977-09-13 1978-09-12 新規なアザシクロアルカン化合物
JP15404678A Pending JPS5492973A (en) 1977-09-13 1978-12-13 Intermediate for synthesis of novel azacycloalkane compound
JP15404578A Granted JPS5495577A (en) 1977-09-13 1978-12-13 Novel azacycloalkane compound and medical composition containing it
JP15404878A Pending JPS5538366A (en) 1977-09-13 1978-12-13 Intermediate for synthesizing novel azacycloalkane compound
JP15404778A Pending JPS5538365A (en) 1977-09-13 1978-12-13 Intermediate for synthesizing novel azacycloalkane compound

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP53112171A Expired JPS5935397B2 (ja) 1977-09-13 1978-09-12 新規なアザシクロアルカン化合物
JP15404678A Pending JPS5492973A (en) 1977-09-13 1978-12-13 Intermediate for synthesis of novel azacycloalkane compound
JP15404578A Granted JPS5495577A (en) 1977-09-13 1978-12-13 Novel azacycloalkane compound and medical composition containing it

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP15404778A Pending JPS5538365A (en) 1977-09-13 1978-12-13 Intermediate for synthesizing novel azacycloalkane compound

Country Status (23)

Country Link
US (1) US4147872A (ja)
JP (5) JPS5935397B2 (ja)
AR (2) AR222019A1 (ja)
AT (1) AT368753B (ja)
AU (1) AU507953B1 (ja)
BE (1) BE870403A (ja)
CA (1) CA1113463A (ja)
CH (1) CH638187A5 (ja)
DE (1) DE2839883A1 (ja)
DK (1) DK401078A (ja)
ES (2) ES473287A1 (ja)
FI (1) FI66173C (ja)
FR (4) FR2401913A1 (ja)
GB (1) GB2004548B (ja)
IE (1) IE47717B1 (ja)
IL (1) IL55555A (ja)
IT (1) IT1099026B (ja)
LU (1) LU80219A1 (ja)
NL (1) NL7809272A (ja)
PH (1) PH15372A (ja)
PT (1) PT68542A (ja)
SE (2) SE7809606L (ja)
YU (1) YU215678A (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
FI792076A7 (fi) * 1978-07-05 1981-01-01 Ciba Geigy Ag Menetelmä uusien fenyylipiperidiinijohdannaisten valmistamiseksi.
US4216218A (en) * 1979-02-23 1980-08-05 American Hoechst Corporation Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
US4312876A (en) * 1979-02-23 1982-01-26 Hoechst-Roussel Pharmaceuticals Incorporated Antidepressive and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
US4302590A (en) * 1979-02-23 1981-11-24 Hoechst-Roussel Pharmaceuticals, Inc. Intermediates for the preparation of 4-aryloxy-3-phenylpiperidines
ZA821888B (en) * 1981-04-01 1983-02-23 Haessle Ab Novel phenyl-piperidines
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4529732A (en) * 1983-03-14 1985-07-16 Pfizer Inc. 2-[2-Hydroxy-4-(substituted)phenyl]piperidines
FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1542948A4 (en) * 2002-08-23 2008-12-17 Univ Connecticut NEW BIPHENYL AND BIPHENYLENE CANNABINOIDS
DE102004036349A1 (de) * 2004-07-27 2006-03-23 Grünenthal GmbH Substituierte 3-Phenylpiperidin-Derivate
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2014125233A2 (fr) 2013-02-14 2014-08-21 Galderma Research & Development Procédé de synthèse de 4-piperidin-4-yl-benzène-1,3-diol et de ses sels et nouveau composé 4-(2,4-dihydroxy-phényl)-4-hydroxy-piperidine-1-carboxylate de tert-butyle

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2310761A1 (fr) * 1975-05-16 1976-12-10 Roussel Uclaf Nouveaux derives de la phenyl-piperidine et leurs sels, procede de preparation et application a titre de medicaments

Also Published As

Publication number Publication date
GB2004548A (en) 1979-04-04
FR2412529A1 (fr) 1979-07-20
JPS5492973A (en) 1979-07-23
DK401078A (da) 1979-03-14
FR2401913A1 (fr) 1979-03-30
FI66173B (fi) 1984-05-31
FR2401913B1 (ja) 1983-01-21
IT7827557A0 (it) 1978-09-12
ES480151A1 (es) 1980-04-01
YU215678A (en) 1983-06-30
JPS5935397B2 (ja) 1984-08-28
FI782793A7 (fi) 1979-03-14
PT68542A (en) 1978-10-01
FR2412531A1 (fr) 1979-07-20
ES473287A1 (es) 1980-03-01
ATA658078A (de) 1982-03-15
AR222019A1 (es) 1981-04-15
IT1099026B (it) 1985-09-18
FR2412530B1 (ja) 1982-11-12
PH15372A (en) 1982-12-10
FR2412531B1 (ja) 1983-01-14
CA1113463A (en) 1981-12-01
IE781837L (en) 1979-03-13
BE870403A (fr) 1979-03-12
AU507953B1 (en) 1980-03-06
FR2412529B1 (ja) 1983-01-14
NL7809272A (nl) 1979-03-15
LU80219A1 (fr) 1980-04-21
IL55555A0 (en) 1978-12-17
DE2839883A1 (de) 1979-03-15
IE47717B1 (en) 1984-05-30
JPS5538365A (en) 1980-03-17
GB2004548B (en) 1982-03-24
IL55555A (en) 1982-08-31
FR2412530A1 (fr) 1979-07-20
AT368753B (de) 1982-11-10
JPS5495577A (en) 1979-07-28
JPS5640155B2 (ja) 1981-09-18
FI66173C (fi) 1984-09-10
SE7809606L (sv) 1979-03-14
JPS5463086A (en) 1979-05-21
SE8305422L (sv) 1983-10-03
SE8305422D0 (sv) 1983-10-03
CH638187A5 (fr) 1983-09-15
US4147872A (en) 1979-04-03
AR220567A1 (es) 1980-11-14

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