JPS5540611A - Preparation of alkyl orthoacetate - Google Patents

Preparation of alkyl orthoacetate

Info

Publication number
JPS5540611A
JPS5540611A JP11294878A JP11294878A JPS5540611A JP S5540611 A JPS5540611 A JP S5540611A JP 11294878 A JP11294878 A JP 11294878A JP 11294878 A JP11294878 A JP 11294878A JP S5540611 A JPS5540611 A JP S5540611A
Authority
JP
Japan
Prior art keywords
formula
alkanol
acetonitrile
compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11294878A
Other languages
Japanese (ja)
Other versions
JPS617180B2 (en
Inventor
Kenichi Hino
Fumito Yamamoto
Takuo Kawaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Original Assignee
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd filed Critical Kuraray Co Ltd
Priority to JP11294878A priority Critical patent/JPS5540611A/en
Publication of JPS5540611A publication Critical patent/JPS5540611A/en
Publication of JPS617180B2 publication Critical patent/JPS617180B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound, useful as e.g. an intermediate for the preparation of pharmaceuticals, continuously, in high yield by reacting acetonitrile, an alkanol and hydrogen chloride in a short time using a specific solvent, and subjecting the products to alcoholysis.
CONSTITUTION: Acetonitrile of formula I, an alkanol of formula II (R=C1W8 alkyl) and hydrogen chloride (more than equimolar amount to the acetonitrile) are made to react at 0W45°C using an acetate of the alkanol, the starting material, as a reaction medium to form an alkyliminoacetate hydro-chloride of formula III (the first step). Then the compound is subjected to the alcoholysis in the presence of a basic substance, which does not generate H2O, while controlling the reaction mixture at pH 2W7, to afford the objective compound of formula IV (the second step).
EFFECT: Purification process of the reaction medium can be omitted, and recovery and reuse of the medium are also possible. The objective compound can be prepared industrially even in a small reaction vessel.
COPYRIGHT: (C)1980,JPO&Japio
JP11294878A 1978-09-14 1978-09-14 Preparation of alkyl orthoacetate Granted JPS5540611A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11294878A JPS5540611A (en) 1978-09-14 1978-09-14 Preparation of alkyl orthoacetate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11294878A JPS5540611A (en) 1978-09-14 1978-09-14 Preparation of alkyl orthoacetate

Publications (2)

Publication Number Publication Date
JPS5540611A true JPS5540611A (en) 1980-03-22
JPS617180B2 JPS617180B2 (en) 1986-03-04

Family

ID=14599518

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11294878A Granted JPS5540611A (en) 1978-09-14 1978-09-14 Preparation of alkyl orthoacetate

Country Status (1)

Country Link
JP (1) JPS5540611A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014208698A (en) * 2007-04-11 2014-11-06 第一三共株式会社 Method for producing neuraminic acid derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014208698A (en) * 2007-04-11 2014-11-06 第一三共株式会社 Method for producing neuraminic acid derivative

Also Published As

Publication number Publication date
JPS617180B2 (en) 1986-03-04

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