JPS5547653A - Novel vitamin d derivative and its preparation - Google Patents

Novel vitamin d derivative and its preparation

Info

Publication number
JPS5547653A
JPS5547653A JP11991578A JP11991578A JPS5547653A JP S5547653 A JPS5547653 A JP S5547653A JP 11991578 A JP11991578 A JP 11991578A JP 11991578 A JP11991578 A JP 11991578A JP S5547653 A JPS5547653 A JP S5547653A
Authority
JP
Japan
Prior art keywords
formula
derivative
preparation
vitamin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11991578A
Other languages
Japanese (ja)
Other versions
JPS6148497B2 (en
Inventor
Kiyoshige Ochi
Isao Matsunaga
Yasuho Nishii
Masafumi Fukushima
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP11991578A priority Critical patent/JPS5547653A/en
Publication of JPS5547653A publication Critical patent/JPS5547653A/en
Publication of JPS6148497B2 publication Critical patent/JPS6148497B2/ja
Granted legal-status Critical Current

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  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:1α-Hydroxyvitamin D3 derivatives of formula I (R is H or hydroxyl).
EXAMPLE: Cholesta-5,7-diene-1α,3β-diol-hemisuccinate.
USE: They have strong vitamin D-like activity and are used as a hapten for preparing the antibody for the determination of vitamin D derivatives by the radioimmunoassay method.
PREPARATION: The reaction between a steroid derivative of formula II and succinic anhydride in the presence of a basic substance as pyridine is effected under an inert atmoshpere as nitrogen. The excess reactants are distilled off and the residue is passed over a column chromatography to form a derivative of formula III in which the 3-position is substituted. The compound of formula III is dissolved in a solvent as hydrocarbon and irradiated with ultraviolet rays at room temperature under an inert atmosphere to be converted into previtamine D3 derivative of formula IV, which is isomerized into title compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP11991578A 1978-09-30 1978-09-30 Novel vitamin d derivative and its preparation Granted JPS5547653A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11991578A JPS5547653A (en) 1978-09-30 1978-09-30 Novel vitamin d derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11991578A JPS5547653A (en) 1978-09-30 1978-09-30 Novel vitamin d derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5547653A true JPS5547653A (en) 1980-04-04
JPS6148497B2 JPS6148497B2 (en) 1986-10-24

Family

ID=14773331

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11991578A Granted JPS5547653A (en) 1978-09-30 1978-09-30 Novel vitamin d derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5547653A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5892656A (en) * 1981-11-30 1983-06-02 Teijin Ltd Novel vitamin d3 derivative and its preparation
JPS59148775A (en) * 1983-02-14 1984-08-25 Teijin Ltd 25-hydroxyvitamin d3-26,23-lactone derivative and its preparation
JPS60130581A (en) * 1983-12-19 1985-07-12 Teijin Ltd Production of 1alpha,25-dihydroxyvitamin d3-26,23-lactone
US5075465A (en) * 1987-10-14 1991-12-24 Toyo Jozo Kabushiki Kaisha 25-hydroxy vitamin d3 derivatives, process for their production, and assay method using the same
US5117018A (en) * 1988-10-05 1992-05-26 Toyo Jozo Kabushiki Kaisha 1α (or 24R), 25-dihydroxy vitamin D3 derivatives
US5202266A (en) * 1987-10-14 1993-04-13 Asahi Kasei Kogyo Kabushiki Kaisha 25-hydroxy vitamin D3 derivatives, process for their production, and assay method using the same
US5214170A (en) * 1988-10-05 1993-05-25 Toyo Jozo Kabushiki Kaisha Radioisotope iodine-labeled 1α (or 24R), 25-dihydroxy vitamin D3

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5892656A (en) * 1981-11-30 1983-06-02 Teijin Ltd Novel vitamin d3 derivative and its preparation
JPS59148775A (en) * 1983-02-14 1984-08-25 Teijin Ltd 25-hydroxyvitamin d3-26,23-lactone derivative and its preparation
JPS60130581A (en) * 1983-12-19 1985-07-12 Teijin Ltd Production of 1alpha,25-dihydroxyvitamin d3-26,23-lactone
US5075465A (en) * 1987-10-14 1991-12-24 Toyo Jozo Kabushiki Kaisha 25-hydroxy vitamin d3 derivatives, process for their production, and assay method using the same
US5202266A (en) * 1987-10-14 1993-04-13 Asahi Kasei Kogyo Kabushiki Kaisha 25-hydroxy vitamin D3 derivatives, process for their production, and assay method using the same
US5117018A (en) * 1988-10-05 1992-05-26 Toyo Jozo Kabushiki Kaisha 1α (or 24R), 25-dihydroxy vitamin D3 derivatives
US5214170A (en) * 1988-10-05 1993-05-25 Toyo Jozo Kabushiki Kaisha Radioisotope iodine-labeled 1α (or 24R), 25-dihydroxy vitamin D3

Also Published As

Publication number Publication date
JPS6148497B2 (en) 1986-10-24

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