JPS5547656A - 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative - Google Patents

2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative

Info

Publication number
JPS5547656A
JPS5547656A JP12067578A JP12067578A JPS5547656A JP S5547656 A JPS5547656 A JP S5547656A JP 12067578 A JP12067578 A JP 12067578A JP 12067578 A JP12067578 A JP 12067578A JP S5547656 A JPS5547656 A JP S5547656A
Authority
JP
Japan
Prior art keywords
derivative
lower alkyl
dihydropyridine
formula
substituted aminoethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12067578A
Other languages
Japanese (ja)
Inventor
Atsuki Nishimura
Jiro Aritomi
Shozo Ueda
Naohito Hatakeno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP12067578A priority Critical patent/JPS5547656A/en
Publication of JPS5547656A publication Critical patent/JPS5547656A/en
Pending legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:2-(2-Substituted aminoethyl)-1,4-dihydropyridine derivative of formula I (R1 is aryl, aromatic heterocycle that may have 1 or 2 substituents as halogen, lower alkoxy or lower alkyl; R2 and R3 are lower alkyl; R4 is lower alkyl; R5 is H, lower alkyl; R6, R7 are lower alkyl, heterocycle).
EXAMPLE: 2-(2-Dimethylaminoethyl)-6-methyl-4-(2-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylic dimethyl ester.
USE: Antistenocardia, antispasmodic, hypotensor.
PREPARATION: The reaction of a compound of formula II with formaldehyde and an amine of formula III or its salt gives the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP12067578A 1978-09-29 1978-09-29 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative Pending JPS5547656A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12067578A JPS5547656A (en) 1978-09-29 1978-09-29 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12067578A JPS5547656A (en) 1978-09-29 1978-09-29 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative

Publications (1)

Publication Number Publication Date
JPS5547656A true JPS5547656A (en) 1980-04-04

Family

ID=14792146

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12067578A Pending JPS5547656A (en) 1978-09-29 1978-09-29 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative

Country Status (1)

Country Link
JP (1) JPS5547656A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
US4539322A (en) * 1982-09-04 1985-09-03 Pfizer Inc. Dihydropyridine derivatives and their use in treating heart conditions and hypertension
US4547502A (en) * 1982-09-04 1985-10-15 Pfizer Inc. Dihydropyridines and their use in treating cardiac conditions and hypertension
US4572908A (en) * 1982-12-21 1986-02-25 Pfizer Inc. Dihydropyridines
JPS6157578A (en) * 1984-08-17 1986-03-24 ジヨン・ワイス・アンド・ブラザー・リミテツド Heterocyclic compound
US4590195A (en) * 1983-03-10 1986-05-20 Pfizer Inc. 4-aryl-3,5-bis(alkoxycarbonyl)-6-methyl-2-aminoalkyloxymethyl-1,4-dihydropyridine antihypertensive agents
US4616024A (en) * 1982-07-22 1986-10-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
EP0089167B1 (en) * 1982-03-11 1986-10-15 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
JPS62240660A (en) * 1986-04-04 1987-10-21 フアイザ−・リミテツド Benzenesulfonate of amurodipine
JPS6341460A (en) * 1986-08-04 1988-02-22 アデイ−ル　エ　コンパニ− Novel dihydrpyridine derivative
JP2014533717A (en) * 2011-11-24 2014-12-15 リピダート クタトー フェイレサト エス タナチャド カーエフテー． 1,4-dihydrpyridine derivatives having Hsp-regulating activity

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089167B1 (en) * 1982-03-11 1986-10-15 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
US4616024A (en) * 1982-07-22 1986-10-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
US4539322A (en) * 1982-09-04 1985-09-03 Pfizer Inc. Dihydropyridine derivatives and their use in treating heart conditions and hypertension
US4547502A (en) * 1982-09-04 1985-10-15 Pfizer Inc. Dihydropyridines and their use in treating cardiac conditions and hypertension
US4572908A (en) * 1982-12-21 1986-02-25 Pfizer Inc. Dihydropyridines
US4661485A (en) * 1982-12-21 1987-04-28 Pfizer Inc. 2-pyrimidylaminoalkoxymethyl-6-methyl-3,5-bis (alkoxycarbony-1)-1,4-dihydropyridine antihypertensive agents
US4670449A (en) * 1982-12-21 1987-06-02 Pfizer Inc. Dihydropyridines
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
US4590195A (en) * 1983-03-10 1986-05-20 Pfizer Inc. 4-aryl-3,5-bis(alkoxycarbonyl)-6-methyl-2-aminoalkyloxymethyl-1,4-dihydropyridine antihypertensive agents
JPS6157578A (en) * 1984-08-17 1986-03-24 ジヨン・ワイス・アンド・ブラザー・リミテツド Heterocyclic compound
US5068337A (en) * 1984-08-17 1991-11-26 John Wyeth & Brother Limited 1,4-dihydropyridines and their ability to inhibit blood platelet aggregation, inhibit thromboxane synthetase and phospholipase
JPS62240660A (en) * 1986-04-04 1987-10-21 フアイザ−・リミテツド Benzenesulfonate of amurodipine
JPS6341460A (en) * 1986-08-04 1988-02-22 アデイ−ル　エ　コンパニ− Novel dihydrpyridine derivative
JP2014533717A (en) * 2011-11-24 2014-12-15 リピダート クタトー フェイレサト エス タナチャド カーエフテー． 1,4-dihydrpyridine derivatives having Hsp-regulating activity

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