JPS5553247A - Novel benzylamine derivative - Google Patents

Novel benzylamine derivative

Info

Publication number
JPS5553247A
JPS5553247A JP12823478A JP12823478A JPS5553247A JP S5553247 A JPS5553247 A JP S5553247A JP 12823478 A JP12823478 A JP 12823478A JP 12823478 A JP12823478 A JP 12823478A JP S5553247 A JPS5553247 A JP S5553247A
Authority
JP
Japan
Prior art keywords
formula
compound
reacted
integer
benzylamine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12823478A
Other languages
Japanese (ja)
Inventor
Kentaro Hirai
Shigeru Matsutani
Teruyuki Ishiha
Itsuo Makino
Toshio Fujishita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP12823478A priority Critical patent/JPS5553247A/en
Publication of JPS5553247A publication Critical patent/JPS5553247A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The compound of formula Ia [R1 is and R2 are independently H, lower alkyl, etc. or unsaturated 4W6 membered hetero cycle comprising 0W1 oxygen atom and 1W2 nitrogen atoms N with formula VI; R3 and R4 are H, hydroxy, etc.; R5 is H, etc.; X is methylene, O, S, etc.; Y is O, S, etc.; m is integer 2W4; n is integer 1W2] and its acid addition salts.
EXAMPLE: 3-{ 2-( 2 -Cyano-4-methylguanidino ) ethylthiomethyl }-N, N-dimethyl benzylamine.
USE: A treating agent for peptic ulcer, having an antihistamine H2 activity as great as metiamide.
PROCESS: The compound of formula II is reacted with dithiocarboxylic acid of formula III in THF, DMSO, etc. to give the compound of formula IV, which is reacted with a primary amine of formula V in a solvent of methanol, etc., to obtain the compound of formula Ia.
COPYRIGHT: (C)1980,JPO&Japio
JP12823478A 1978-10-17 1978-10-17 Novel benzylamine derivative Pending JPS5553247A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12823478A JPS5553247A (en) 1978-10-17 1978-10-17 Novel benzylamine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12823478A JPS5553247A (en) 1978-10-17 1978-10-17 Novel benzylamine derivative

Publications (1)

Publication Number Publication Date
JPS5553247A true JPS5553247A (en) 1980-04-18

Family

ID=14979800

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12823478A Pending JPS5553247A (en) 1978-10-17 1978-10-17 Novel benzylamine derivative

Country Status (1)

Country Link
JP (1) JPS5553247A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5770857A (en) * 1980-07-30 1982-05-01 Ici Ltd Guanidine derivative, manufacture and histamine h-2 antagonist containing same
JPS57165348A (en) * 1981-04-06 1982-10-12 Teikoku Hormone Mfg Co Ltd Novel aminoalkylbenzene derivative
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5770857A (en) * 1980-07-30 1982-05-01 Ici Ltd Guanidine derivative, manufacture and histamine h-2 antagonist containing same
JPS57165348A (en) * 1981-04-06 1982-10-12 Teikoku Hormone Mfg Co Ltd Novel aminoalkylbenzene derivative
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

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