JPS5562016A - Antidepressive comprising amidinohydrazone derivative - Google Patents
Antidepressive comprising amidinohydrazone derivativeInfo
- Publication number
- JPS5562016A JPS5562016A JP13375378A JP13375378A JPS5562016A JP S5562016 A JPS5562016 A JP S5562016A JP 13375378 A JP13375378 A JP 13375378A JP 13375378 A JP13375378 A JP 13375378A JP S5562016 A JPS5562016 A JP S5562016A
- Authority
- JP
- Japan
- Prior art keywords
- antidepressive
- derivative
- amidinohydrazone
- salt
- 1w25mg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001430 anti-depressive effect Effects 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 abstract 1
- 208000004130 Blepharoptosis Diseases 0.000 abstract 1
- 206010015995 Eyelid ptosis Diseases 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 abstract 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 abstract 1
- -1 amidino hydrazone derivative Chemical class 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 abstract 1
- 229960004801 imipramine Drugs 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 201000003004 ptosis Diseases 0.000 abstract 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 abstract 1
- 229960003147 reserpine Drugs 0.000 abstract 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: An antidepressive drug having the same action as Imipramine, comprising a specific amidinohydrazone derivative and its salt.
CONSTITUTION: An antidepressive comprising an amidino hydrazone derivative of the formula [R is phenyl or 2-(p-alkoxyphenyl)-1-methyl-ethylene] or its nontoxic salt. The compound is well known as an antiviral agent, and the antidepressive activity is determined by the reserpine blepharoptosis antagonism tests in mice. The effective dose is preferably 1W25mg/kg.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13375378A JPS5562016A (en) | 1978-11-01 | 1978-11-01 | Antidepressive comprising amidinohydrazone derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13375378A JPS5562016A (en) | 1978-11-01 | 1978-11-01 | Antidepressive comprising amidinohydrazone derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5562016A true JPS5562016A (en) | 1980-05-10 |
Family
ID=15112125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13375378A Pending JPS5562016A (en) | 1978-11-01 | 1978-11-01 | Antidepressive comprising amidinohydrazone derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5562016A (en) |
-
1978
- 1978-11-01 JP JP13375378A patent/JPS5562016A/en active Pending
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