JPS5562017A - Anti-inflammatory agent comprising guanidine derivative - Google Patents
Anti-inflammatory agent comprising guanidine derivativeInfo
- Publication number
- JPS5562017A JPS5562017A JP13375278A JP13375278A JPS5562017A JP S5562017 A JPS5562017 A JP S5562017A JP 13375278 A JP13375278 A JP 13375278A JP 13375278 A JP13375278 A JP 13375278A JP S5562017 A JPS5562017 A JP S5562017A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- inflammatory agent
- salts
- guanidine derivative
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 150000002357 guanidines Chemical class 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- -1 nitro, acetamido group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: A drug having anti-allergic and anti-inflammatory actions, comprising a specific guanidine derevative or its salts as an active constituent.
CONSTITUTION: A drug comprising one or two or more types of guanidine derivatives of the formula (R1 is H, OH, 1W10C alkoxy, halogen, nitro, acetamido group, etc.; R2 is H, lower alkyl group, etc.; R3, R4 and R5 are H, lower alkyl groups, etc.; n is 0 or 1) or their salts. The compounds are well known, and the effective amount is 20W50mg/kg as an anti-inflammatory drug and 50W100mg/kg against asthma, allergic rhinitis, and nettle rash.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13375278A JPS5562017A (en) | 1978-11-01 | 1978-11-01 | Anti-inflammatory agent comprising guanidine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13375278A JPS5562017A (en) | 1978-11-01 | 1978-11-01 | Anti-inflammatory agent comprising guanidine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5562017A true JPS5562017A (en) | 1980-05-10 |
Family
ID=15112101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13375278A Pending JPS5562017A (en) | 1978-11-01 | 1978-11-01 | Anti-inflammatory agent comprising guanidine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5562017A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992019236A1 (en) * | 1991-05-07 | 1992-11-12 | The Rockefeller University | 2-alkylidene-aminoguanidines for inhibiting advanced nonenzymaticglycosylation of proteins |
| US7153881B2 (en) | 2000-08-07 | 2006-12-26 | Acure Pharma Ab | Compounds acting as melanocortin receptor ligands |
| US8148429B2 (en) | 2000-08-07 | 2012-04-03 | Anamar Ab | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands |
-
1978
- 1978-11-01 JP JP13375278A patent/JPS5562017A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992019236A1 (en) * | 1991-05-07 | 1992-11-12 | The Rockefeller University | 2-alkylidene-aminoguanidines for inhibiting advanced nonenzymaticglycosylation of proteins |
| US7153881B2 (en) | 2000-08-07 | 2006-12-26 | Acure Pharma Ab | Compounds acting as melanocortin receptor ligands |
| US8148429B2 (en) | 2000-08-07 | 2012-04-03 | Anamar Ab | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands |
| US8309609B2 (en) | 2000-08-07 | 2012-11-13 | Anamar Ab | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands |
| US9227927B2 (en) | 2000-08-07 | 2016-01-05 | Anamar Ab | Method of treating inflammation |
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