JPS5571701A - Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient - Google Patents
Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredientInfo
- Publication number
- JPS5571701A JPS5571701A JP14517578A JP14517578A JPS5571701A JP S5571701 A JPS5571701 A JP S5571701A JP 14517578 A JP14517578 A JP 14517578A JP 14517578 A JP14517578 A JP 14517578A JP S5571701 A JPS5571701 A JP S5571701A
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- hydrolyzate
- formic acid
- added
- immunoregulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000004676 glycans Chemical class 0.000 title abstract 8
- 229920001282 polysaccharide Polymers 0.000 title abstract 8
- 239000005017 polysaccharide Substances 0.000 title abstract 8
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 8
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 4
- 235000019253 formic acid Nutrition 0.000 abstract 4
- 241000233866 Fungi Species 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 241000221198 Basidiomycota Species 0.000 abstract 1
- 241000222384 Corticiaceae Species 0.000 abstract 1
- 241001529717 Corticium <basidiomycota> Species 0.000 abstract 1
- 229920001503 Glucan Polymers 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 230000006198 deformylation Effects 0.000 abstract 1
- 238000006344 deformylation reaction Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
PURPOSE: To obtain a hydrolyzate polysaccharide useful for an immunoregulator of cancer, anticular rheumatism, etc., easily soluble in water and capable of forming an aqueous solution scarcely being gelled, by treating a polysaccharide produced by a fungus of corticiaceal with formic acid, followed by hydrolysis.
CONSTITUTION: A polysaccharide, which basidiomycete, a fungus of corticiaceae, for example, a genus of corticium, produces as a metabolic product, is treated with formic acid, and hydrolyzed. In the preparation of a hydrolyzate polysaccharide from the polysaccharide, a starting material, for example, 70W90wt% formic acid is added to the polysaccharide, and stirred at 80W100°C for from 5 minutes to one hour. Formic acid is removed under pressure, water is added to the residue and reflux under heating is continued until deformylation is over. The resulting gelatinous material is removed by centrifugation,an organic solvent is added to the supernatant liquid to precipitate deposists, which are collected. A glucan consisting of β-(1→3) bond as a backbone chain and β-(1→6) bond as a side chain is obtained.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14517578A JPS5571701A (en) | 1978-11-24 | 1978-11-24 | Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14517578A JPS5571701A (en) | 1978-11-24 | 1978-11-24 | Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5571701A true JPS5571701A (en) | 1980-05-30 |
Family
ID=15379159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14517578A Pending JPS5571701A (en) | 1978-11-24 | 1978-11-24 | Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5571701A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02256620A (en) * | 1989-02-20 | 1990-10-17 | Taito Kk | Composition and method for enhancing effect of fish vaccine |
| US5322841A (en) * | 1989-09-08 | 1994-06-21 | Alpha-Beta Technology, Inc. | Method for producing neutral glucans for pharmaceutical applications |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5633369A (en) * | 1989-09-08 | 1997-05-27 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US6046323A (en) * | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
| US6369216B1 (en) | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| US7022685B2 (en) | 1998-09-25 | 2006-04-04 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
-
1978
- 1978-11-24 JP JP14517578A patent/JPS5571701A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02256620A (en) * | 1989-02-20 | 1990-10-17 | Taito Kk | Composition and method for enhancing effect of fish vaccine |
| US5849720A (en) * | 1989-09-08 | 1998-12-15 | Alpha-Beta Technology, Inc. | Enhancement of non-specific immune defenses by administration of underivatized, aqueous soluble glucans |
| US5322841A (en) * | 1989-09-08 | 1994-06-21 | Alpha-Beta Technology, Inc. | Method for producing neutral glucans for pharmaceutical applications |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| US5532223A (en) * | 1989-09-08 | 1996-07-02 | Alpha-Beta Technology, Inc. | Use of aqueous soluble glucan preparations to stimulate platelet production |
| US5633369A (en) * | 1989-09-08 | 1997-05-27 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US5663324A (en) * | 1989-09-08 | 1997-09-02 | Alpha-Beta Technology, Inc. | Method for producing underivatized, aqueous soluble β(1-3) glucan |
| US5811542A (en) * | 1989-09-08 | 1998-09-22 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5783569A (en) * | 1992-08-21 | 1998-07-21 | Alpha-Beta Technology, Inc. | Uses for underivatized, aqueous soluble β(1-3) glucan and compositions comprising same |
| US5817643A (en) * | 1992-08-21 | 1998-10-06 | Alpha-Beta Technology, Inc. | Underivatized, aqueous soluable β(1-3) glucan, composition and method of making same |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| US6046323A (en) * | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
| US6369216B1 (en) | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| US7022685B2 (en) | 1998-09-25 | 2006-04-04 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
| US7566704B2 (en) | 1998-09-25 | 2009-07-28 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU562078B2 (en) | Preparation of 2-hydroxy-4-methyl timobutyric acid | |
| SU572201A3 (en) | Method of preparing methyl ester of 5-propyltio-2-benzimidazolcarbamic acid | |
| ES435051A1 (en) | Process for extracting and processing glycoproteins, mucopolysaccharides and accompanying substances | |
| CA2103086A1 (en) | Clear Antiperspirant Gel Stick and Method for Making Same | |
| JPS5571701A (en) | Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient | |
| JPH1099043A5 (en) | ||
| KR890008031A (en) | Method for producing titanium dioxide powder | |
| CA2037248A1 (en) | Process for the production of dried pasta | |
| CH611797A5 (en) | Process for the preparation of pilocarpine pamoate | |
| US2488564A (en) | Preparation of hyaluronidase | |
| JPS5716674A (en) | Preparation of acidic emulsified food | |
| JPS5714534A (en) | Protein rbf-pm | |
| JP3216056B2 (en) | Immunostimulating substance, water-soluble paramylon and method for producing the same | |
| JPS573827A (en) | Production of solubilized silk peptide and skin cosmetics containing the same | |
| JPS5576817A (en) | Agent for improving blood vessel function | |
| JPS57129652A (en) | Production of soybean protein material | |
| GB1543391A (en) | Process for obtaining extracts from embryonic calf skins extracts so obtained and cosmetic and pharmaceutical compositions containing these extracts | |
| GB1510046A (en) | Process for the recovery of formaldehyde as hexamine from waste waters | |
| JPS57155974A (en) | Preparation of concentrated barley water | |
| GB1381418A (en) | Recovery of ammonium salts of organic acids | |
| JPS56121444A (en) | Preparation of jelly substance | |
| US2166133A (en) | Therapeutically valuable gold compounds and a method for producing the same | |
| JPS5718969A (en) | Preparation of organic complex from essential nutrient metallic element | |
| JPS5412369A (en) | Preparation of thienylacetic acid | |
| JPS57159493A (en) | Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester |