JPS557228A - Enzyme preparation - Google Patents
Enzyme preparationInfo
- Publication number
- JPS557228A JPS557228A JP7908178A JP7908178A JPS557228A JP S557228 A JPS557228 A JP S557228A JP 7908178 A JP7908178 A JP 7908178A JP 7908178 A JP7908178 A JP 7908178A JP S557228 A JPS557228 A JP S557228A
- Authority
- JP
- Japan
- Prior art keywords
- water
- oil
- enzyme
- phase contains
- water phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000790 Enzymes Proteins 0.000 title abstract 5
- 102000004190 Enzymes Human genes 0.000 title abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 7
- 229940088598 enzyme Drugs 0.000 abstract 4
- 239000002131 composite material Substances 0.000 abstract 2
- 239000003995 emulsifying agent Substances 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 abstract 1
- 102000004452 Arginase Human genes 0.000 abstract 1
- 108700024123 Arginases Proteins 0.000 abstract 1
- 108010024976 Asparaginase Proteins 0.000 abstract 1
- 102000016943 Muramidase Human genes 0.000 abstract 1
- 108010014251 Muramidase Proteins 0.000 abstract 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 229960000274 lysozyme Drugs 0.000 abstract 1
- 235000010335 lysozyme Nutrition 0.000 abstract 1
- 239000004325 lysozyme Substances 0.000 abstract 1
- 150000002772 monosaccharides Chemical class 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
- 229960005356 urokinase Drugs 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE: To obtain an enzyme preparation having improved stability and capable of being administered even by injection, composed of a water/oil/water composite emulsion wherein the innermost water phase contains the enzyme.
CONSTITUTION: A water/oil/water-type composite emulsion wherein the inner water phase contains an enzyme (e.g. L-asparaginase, arginase, urokinase, lysozyme, etc.) The outer water phase contains a weak alkali salt and a water-soluble emulsifier, and the oil phase contains the oil component, a fatty acid and an oil- soluble emulsifier. The inner water phase pref. contains a monosaccharide, sugar alcohol, etc. The preparation has similar activity to the micro-encapsulated enzyme and high stability, inhibits the antigen-antibody reaction, and can be administered in high dose.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7908178A JPS557228A (en) | 1978-06-29 | 1978-06-29 | Enzyme preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7908178A JPS557228A (en) | 1978-06-29 | 1978-06-29 | Enzyme preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS557228A true JPS557228A (en) | 1980-01-19 |
| JPS633848B2 JPS633848B2 (en) | 1988-01-26 |
Family
ID=13679936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7908178A Granted JPS557228A (en) | 1978-06-29 | 1978-06-29 | Enzyme preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS557228A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5643209A (en) * | 1979-09-14 | 1981-04-21 | Kowa Co | External drug of urokinase |
| JPH09511744A (en) * | 1994-04-07 | 1997-11-25 | ファーマヴィーン，インコーポレイテッド | Multi-layer drug delivery system |
| WO2005023282A1 (en) * | 2003-09-03 | 2005-03-17 | Ltt Bio-Pharma Co., Ltd. | Nanoparticle containing physiologically active protein or peptide, process for producing the same and external preparation comprising the nanoparticle |
| JP2014509602A (en) * | 2011-03-14 | 2014-04-21 | ドラッグ デリバリー ソリューションズ リミテッド | Ophthalmic composition |
| JP2014221043A (en) * | 2014-06-04 | 2014-11-27 | 学校法人神奈川大学 | W/o/w type emulsion, enzyme preservation liquid of w/o/w type emulsion, and enzyme preservation method |
-
1978
- 1978-06-29 JP JP7908178A patent/JPS557228A/en active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5643209A (en) * | 1979-09-14 | 1981-04-21 | Kowa Co | External drug of urokinase |
| JPH09511744A (en) * | 1994-04-07 | 1997-11-25 | ファーマヴィーン，インコーポレイテッド | Multi-layer drug delivery system |
| WO2005023282A1 (en) * | 2003-09-03 | 2005-03-17 | Ltt Bio-Pharma Co., Ltd. | Nanoparticle containing physiologically active protein or peptide, process for producing the same and external preparation comprising the nanoparticle |
| JP2014509602A (en) * | 2011-03-14 | 2014-04-21 | ドラッグ デリバリー ソリューションズ リミテッド | Ophthalmic composition |
| JP2014221043A (en) * | 2014-06-04 | 2014-11-27 | 学校法人神奈川大学 | W/o/w type emulsion, enzyme preservation liquid of w/o/w type emulsion, and enzyme preservation method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS633848B2 (en) | 1988-01-26 |
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