JPS5583761A - Novel 3-phenyl-4-quinazolone derivative - Google Patents

Novel 3-phenyl-4-quinazolone derivative

Info

Publication number
JPS5583761A
JPS5583761A JP15576478A JP15576478A JPS5583761A JP S5583761 A JPS5583761 A JP S5583761A JP 15576478 A JP15576478 A JP 15576478A JP 15576478 A JP15576478 A JP 15576478A JP S5583761 A JPS5583761 A JP S5583761A
Authority
JP
Japan
Prior art keywords
alkyl
phenyl
compound
activity
quinazolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15576478A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Masao Eguchi
Hiromichi Tanaka
Shigeru Ito
Yoshimi Takashima
Masahiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP15576478A priority Critical patent/JPS5583761A/en
Priority to NZ192392A priority patent/NZ192392A/en
Priority to YU03063/79A priority patent/YU306379A/en
Priority to US06/103,841 priority patent/US4276295A/en
Priority to DE19792950376 priority patent/DE2950376A1/en
Priority to AU53932/79A priority patent/AU526309B2/en
Priority to AR279316A priority patent/AR225028A1/en
Priority to SE7910376A priority patent/SE7910376L/en
Priority to IT28062/79A priority patent/IT1126577B/en
Priority to DK539979A priority patent/DK539979A/en
Priority to NO794135A priority patent/NO794135L/en
Priority to GB7943565A priority patent/GB2040927B/en
Priority to NL7909118A priority patent/NL7909118A/en
Priority to DD79217854A priority patent/DD150462A5/en
Priority to HU79II311A priority patent/HU182733B/en
Priority to CA342,295A priority patent/CA1111849A/en
Priority to FR7931059A priority patent/FR2444671A1/en
Priority to BE0/198633A priority patent/BE880720A/en
Priority to CH1125779A priority patent/CH644112A5/en
Priority to AT0801179A priority patent/AT375651B/en
Priority to ZA00796892A priority patent/ZA796892B/en
Publication of JPS5583761A publication Critical patent/JPS5583761A/en
Priority to ES493758A priority patent/ES493758A0/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A 3-phenyl-4-quinazolone derivative of formula I (R1,2 are lower alkyl; R3 is alkyl; R4,5 are H, halogen, alkyl, or alkoxy; R6 is H, halogen, alkyl, alkoxy, trifluoromethyl, nitro, or R4 and R5 together form methylenedioxy group).
EXAMPLE: 6-Ethoxycarbonyl-5,7-dimethyl-3-phenyl-4-quinazolone.
USE: Drug having anti-thromboxane activity and blood vessel smooth muscle relaxation activity, and effective for the prevention and remedy of ischemic cerebral vascular lesion, ischemic cardiopathy and thrombosis, as well as drug having blonco-dilating activity.
PROCESS: The compound I is prepared by reacting 1mol of a compound II (R is H or lower alkyl) with 1W1.2mol of a compound III at 150W250°C, pref. about 200°C.
COPYRIGHT: (C)1980,JPO&Japio
JP15576478A 1978-12-19 1978-12-19 Novel 3-phenyl-4-quinazolone derivative Pending JPS5583761A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
JP15576478A JPS5583761A (en) 1978-12-19 1978-12-19 Novel 3-phenyl-4-quinazolone derivative
NZ192392A NZ192392A (en) 1978-12-19 1979-12-13 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones
YU03063/79A YU306379A (en) 1978-12-19 1979-12-14 Process for producing 3-aromatically substituted 4(3h)-quinazolines
US06/103,841 US4276295A (en) 1978-12-19 1979-12-14 3-Aromatic moiety substituted-4(3H)-quinazolinones, process for production thereof, and use thereof
DE19792950376 DE2950376A1 (en) 1978-12-19 1979-12-14 4 (3H) -QUINAZOLINONES SUBSTITUTED IN A 3-POSITION WITH AROMATIC GROUP AND METHOD FOR THE PRODUCTION AND USE THEREOF
AU53932/79A AU526309B2 (en) 1978-12-19 1979-12-17 Substituted quinazolinones
AR279316A AR225028A1 (en) 1978-12-19 1979-12-17 A PROCEDURE FOR PRODUCING A 4 (3H) -QUINAZOLINONE 3-PHENYL OR PIRIDIL-SUBSTITUTED
SE7910376A SE7910376L (en) 1978-12-19 1979-12-17 quinazolinone derivatives
IT28062/79A IT1126577B (en) 1978-12-19 1979-12-17 4 (3H) -CHINAZOLINONES REPLACED IN THE 3-AROMATIC HALF, PROCEDURE FOR THEIR PRODUCTION AND USE
GB7943565A GB2040927B (en) 1978-12-19 1979-12-18 Pharmaceutically active 3 - aromatic moiety substituted - 4 (3h) - quinazolinone derivatives
NO794135A NO794135L (en) 1978-12-19 1979-12-18 SUBSTITUTED 4 (3H) CHINAZOLINONES, PROCEDURE FOR THE PREPARATION AND USE OF THESE
DK539979A DK539979A (en) 1978-12-19 1979-12-18 QUINAZOLINO DERIVATIVES AND THEIR PREPARATION AND USE
NL7909118A NL7909118A (en) 1978-12-19 1979-12-18 SUBSTITUTED CHINAZOLIN DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS AN ACTIVE COMPONENT.
FR7931059A FR2444671A1 (en) 1978-12-19 1979-12-19 NEW QUINAZOLINONES, THEIR PREPARATION AND THE MEDICINE CONTAINING THESE SUBSTANCES
HU79II311A HU182733B (en) 1978-12-19 1979-12-19 Process for producing substituted quinazoline-derivatives
CA342,295A CA1111849A (en) 1978-12-19 1979-12-19 3-aromatic moiety substituted-4(3h)-quinazolinones, process for production thereof, and use thereof
DD79217854A DD150462A5 (en) 1978-12-19 1979-12-19 PROCESS FOR PREPARING 4 (3H) -CHINAZOLINONES SUBSTITUTED IN 3-POSITION WITH AROMATIC GROUP
BE0/198633A BE880720A (en) 1978-12-19 1979-12-19 NOVEL 4 (3H) -QUINAZOLINONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY AN AROMATIC PORTION, THEIR PREPARATION AND THEIR USE
CH1125779A CH644112A5 (en) 1978-12-19 1979-12-19 3-AROMATIC-SUBSTITUTED-4 (3H) CHINAZOLINONES AND METHOD FOR THE PRODUCTION THEREOF.
AT0801179A AT375651B (en) 1978-12-19 1979-12-19 METHOD FOR PRODUCING NEW 3-POSITION AROMATICALLY SUBSTITUTED 4 (3H) -CHINAZOLINONE DERIVATIVES AND THEIR ACID ADDITION SALTS
ZA00796892A ZA796892B (en) 1978-12-19 1979-12-19 3-aromatic moiety substituted-(3h)-quinazolinones, process for production thereof, and use tereof
ES493758A ES493758A0 (en) 1978-12-19 1980-07-28 A PROCEDURE FOR PRODUCING A 4 (3H) -QUINAZOLINONE SUBSTITUTED WITH AN AROMATIC REST IN POSITION 3Ÿ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15576478A JPS5583761A (en) 1978-12-19 1978-12-19 Novel 3-phenyl-4-quinazolone derivative

Publications (1)

Publication Number Publication Date
JPS5583761A true JPS5583761A (en) 1980-06-24

Family

ID=15612890

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15576478A Pending JPS5583761A (en) 1978-12-19 1978-12-19 Novel 3-phenyl-4-quinazolone derivative

Country Status (4)

Country Link
JP (1) JPS5583761A (en)
AT (1) AT375651B (en)
BE (1) BE880720A (en)
ZA (1) ZA796892B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59106195A (en) * 1982-12-10 1984-06-19 富士通株式会社 Method of indicating number of thick film pattern printing

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59106195A (en) * 1982-12-10 1984-06-19 富士通株式会社 Method of indicating number of thick film pattern printing

Also Published As

Publication number Publication date
ATA801179A (en) 1984-01-15
BE880720A (en) 1980-06-19
ZA796892B (en) 1980-12-31
AT375651B (en) 1984-08-27

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