JPS5583776A - 4,5,6,7-dehydro pgi1 derivative - Google Patents
4,5,6,7-dehydro pgi1 derivativeInfo
- Publication number
- JPS5583776A JPS5583776A JP15688578A JP15688578A JPS5583776A JP S5583776 A JPS5583776 A JP S5583776A JP 15688578 A JP15688578 A JP 15688578A JP 15688578 A JP15688578 A JP 15688578A JP S5583776 A JPS5583776 A JP S5583776A
- Authority
- JP
- Japan
- Prior art keywords
- pgi
- dehydro
- derivative
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101150040663 PGI1 gene Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- KAQKFAOMNZTLHT-OZUDYXHBSA-N prostaglandin I2 Chemical compound O1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-OZUDYXHBSA-N 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000810 peripheral vasodilating agent Substances 0.000 abstract 1
- 229960002116 peripheral vasodilator Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003169 prostaglandin F2α derivatives Chemical class 0.000 abstract 1
Landscapes
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:4,5,6,7-Dehydro PGI1 derivative of formula VI: (R1 is H, 1W12C alkyl, 3W10C cycloalkyl, 7W12C aralkyl, phenyl group, etc.; R2 is 1W12C alkyl, or alkyl, 3W10C cycloalkyl, or 7W12C aralkyl group which may have 0W5 oxygen atoms linked to any positions).
EXAMPLE: 4,5,6,7-Dehydro PGI1-methyl ester.
USE: Medicines similar to PGI2 having blood platelet antiagglutinative, gastric acid secretion inhibitory, and peripheral vasodilator actions. The structural instability is eliminated while retaining the 6,9α-epoxy structure which is important to PGI2.
PROCESS: A compound obtained from a PGF2α derivative by the singlet oxygen is oxidized, cyclized, and deacetylated to give the compound of formula VI.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15688578A JPS5583776A (en) | 1978-12-21 | 1978-12-21 | 4,5,6,7-dehydro pgi1 derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15688578A JPS5583776A (en) | 1978-12-21 | 1978-12-21 | 4,5,6,7-dehydro pgi1 derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5583776A true JPS5583776A (en) | 1980-06-24 |
| JPS6215550B2 JPS6215550B2 (en) | 1987-04-08 |
Family
ID=15637511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15688578A Granted JPS5583776A (en) | 1978-12-21 | 1978-12-21 | 4,5,6,7-dehydro pgi1 derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5583776A (en) |
-
1978
- 1978-12-21 JP JP15688578A patent/JPS5583776A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6215550B2 (en) | 1987-04-08 |
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