JPS5585578A - Prostaglandin i2 derivative - Google Patents

Prostaglandin i2 derivative

Info

Publication number
JPS5585578A
JPS5585578A JP15758978A JP15758978A JPS5585578A JP S5585578 A JPS5585578 A JP S5585578A JP 15758978 A JP15758978 A JP 15758978A JP 15758978 A JP15758978 A JP 15758978A JP S5585578 A JPS5585578 A JP S5585578A
Authority
JP
Japan
Prior art keywords
formula
compound
pgi2
prostaglandin
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15758978A
Other languages
Japanese (ja)
Other versions
JPS6215551B2 (en
Inventor
Hisao Nishiyama
Kiyotaka Ono
Shintaro Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP15758978A priority Critical patent/JPS5585578A/en
Publication of JPS5585578A publication Critical patent/JPS5585578A/en
Publication of JPS6215551B2 publication Critical patent/JPS6215551B2/ja
Granted legal-status Critical Current

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  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Prostaglandin I2 derivatives of formula VI[R is -OCH2COOC2H5, -OCH(CH3)COOC2H5, -OCH2CH2OCH3, -(OCH2CH2)3OH, phthalidoxy, -OC H2CH2N(CH2CH2OH)2, 2-(2-pyridyl)ethocy, 2-(6-hydroxypyridyl)methoxy, N- cyclohexylamide, N,N'-dicyclohexylureide]. EXAMPLE:PGI2 methoxyethyl ester. USE:Hypotensor and antithrombosis; the products sustain the equal or superior pharmaceutical activities to those of PGI2 and remove the structural instability under neutral and acidic conditions, thus permitting oral administration. PREPARATION:The compound of formula III is esterified or amidated and the resulting compound is cyclized intramolecularly. The product of formula V is subjected to dehydroiodization to give the objective compound of formula VI.
JP15758978A 1978-12-22 1978-12-22 Prostaglandin i2 derivative Granted JPS5585578A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15758978A JPS5585578A (en) 1978-12-22 1978-12-22 Prostaglandin i2 derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15758978A JPS5585578A (en) 1978-12-22 1978-12-22 Prostaglandin i2 derivative

Publications (2)

Publication Number Publication Date
JPS5585578A true JPS5585578A (en) 1980-06-27
JPS6215551B2 JPS6215551B2 (en) 1987-04-08

Family

ID=15653000

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15758978A Granted JPS5585578A (en) 1978-12-22 1978-12-22 Prostaglandin i2 derivative

Country Status (1)

Country Link
JP (1) JPS5585578A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6013779A (en) * 1983-07-05 1985-01-24 Green Cross Corp:The Prostaglandin i2 derivative
JP2013231038A (en) * 2013-06-04 2013-11-14 Techfields Biochem Co Ltd Positively charged water-soluble prodrug of prostaglandin and related compound having very high skin-penetration rate
JP2015134801A (en) * 2015-03-09 2015-07-27 テックフィールズ バイオケム カンパニー リミテッド Prostaglandin and positively charged water-soluble prodrug of related compound having very high skin penetration rate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5446773A (en) * 1977-09-22 1979-04-12 Ono Pharmaceut Co Ltd Prostaglandin i2 analog and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5446773A (en) * 1977-09-22 1979-04-12 Ono Pharmaceut Co Ltd Prostaglandin i2 analog and its preparation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6013779A (en) * 1983-07-05 1985-01-24 Green Cross Corp:The Prostaglandin i2 derivative
US4613614A (en) * 1983-07-05 1986-09-23 The Green Cross Corporation Prostaglandin I2 ester and fat emulsion containing the same
JP2013231038A (en) * 2013-06-04 2013-11-14 Techfields Biochem Co Ltd Positively charged water-soluble prodrug of prostaglandin and related compound having very high skin-penetration rate
JP2015134801A (en) * 2015-03-09 2015-07-27 テックフィールズ バイオケム カンパニー リミテッド Prostaglandin and positively charged water-soluble prodrug of related compound having very high skin penetration rate

Also Published As

Publication number Publication date
JPS6215551B2 (en) 1987-04-08

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