JPS5587779A - Epoxyditerpene - Google Patents
EpoxyditerpeneInfo
- Publication number
- JPS5587779A JPS5587779A JP16077178A JP16077178A JPS5587779A JP S5587779 A JPS5587779 A JP S5587779A JP 16077178 A JP16077178 A JP 16077178A JP 16077178 A JP16077178 A JP 16077178A JP S5587779 A JPS5587779 A JP S5587779A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- react
- day
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 abstract 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 abstract 1
- 125000005287 vanadyl group Chemical group 0.000 abstract 1
Landscapes
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:1β-Acetoxy-13, 14β-epoxy-2β-( 1-hydroxy-1-methylethyl )5, 9, 13α-trimethylcyclotetradecane-5,9-diene of formula I (Ac is acetyl).
USE: A medicine having carcinostatic acitivity. The dosage is about 5W3000mg/kg, preferably about 25W1000mg/kg.day in portions and it is orally or nonorally administered twice to five times a day.
PREPARATION: 2β-Isopropenyl-5, 9, 13-trimethylcyclotetradeca-5, 9, 13-trien-1β- ol is epoxidized with t-butylhydroperoxide in the presence of vanadyl acetoacetonate and the product is made to react with acetic anhydride to give a compound of formula III. Pyridine hydrochloride is made to react with the compound of formula III to form a compound of formula IV, which is made to react with tri-n-butyltin hydride to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16077178A JPS5587779A (en) | 1978-12-26 | 1978-12-26 | Epoxyditerpene |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16077178A JPS5587779A (en) | 1978-12-26 | 1978-12-26 | Epoxyditerpene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5587779A true JPS5587779A (en) | 1980-07-02 |
| JPS6154028B2 JPS6154028B2 (en) | 1986-11-20 |
Family
ID=15722093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16077178A Granted JPS5587779A (en) | 1978-12-26 | 1978-12-26 | Epoxyditerpene |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5587779A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1351678A2 (en) * | 2001-01-02 | 2003-10-15 | Elizabeth Shanahan-Prendergast | Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens |
-
1978
- 1978-12-26 JP JP16077178A patent/JPS5587779A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1351678A2 (en) * | 2001-01-02 | 2003-10-15 | Elizabeth Shanahan-Prendergast | Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6154028B2 (en) | 1986-11-20 |
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