JPS5587783A - Hexahydrobenzofuranacetic acid derivative and anti-inflammatory analgesic - Google Patents

Hexahydrobenzofuranacetic acid derivative and anti-inflammatory analgesic

Info

Publication number
JPS5587783A
JPS5587783A JP16380378A JP16380378A JPS5587783A JP S5587783 A JPS5587783 A JP S5587783A JP 16380378 A JP16380378 A JP 16380378A JP 16380378 A JP16380378 A JP 16380378A JP S5587783 A JPS5587783 A JP S5587783A
Authority
JP
Japan
Prior art keywords
formula
inflammatory analgesic
hexahydrobenzofuranacetic
thioacetamide
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16380378A
Other languages
Japanese (ja)
Inventor
Yoshio Hayashi
Susumu Mizogami
Mitsuo Hanatsuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Yuka Pharmaceutical Co Ltd
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Yuka Pharmaceutical Co Ltd
Mitsubishi Petrochemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Yuka Pharmaceutical Co Ltd, Mitsubishi Petrochemical Co Ltd filed Critical Mitsubishi Yuka Pharmaceutical Co Ltd
Priority to JP16380378A priority Critical patent/JPS5587783A/en
Publication of JPS5587783A publication Critical patent/JPS5587783A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

NEW MATERIAL:5a,6,7,8,9,9a-Hexahydrodibenzofuranacetic acids of formula I (R1 is H, methyl; R2 is H, 1W4C alkyl; X is H, 1W6C alkyl, 4W7C cycloalkyl, phenyl; Y is hydroxyl, 1W4C alkoxyl), their derivatives and salts.
EXAMPLE: 5a,6,7,8,9,9a-Hexahydro-2-dibenzofuranacetic acid.
USE: Anti-inflammatory analgesic, which has high pharmaceutical activity, low toxicity and side-effects.
PREPARATION: A compound of formula II (R2, X are the same as those in formula I) is acetylated with acetyl chloride in the presence of a Lewis acid and the product is made to react with sulfur and a secondary amine as morpholine to give the thioacetamide. The thioacetamide is heated under reflux in an aqueous potassium hydroxide or a solvent mix of water and organic solvent to give the objective compound of formula I where R1 is H and Y is hydroxyl.
COPYRIGHT: (C)1980,JPO&Japio
JP16380378A 1978-12-26 1978-12-26 Hexahydrobenzofuranacetic acid derivative and anti-inflammatory analgesic Pending JPS5587783A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16380378A JPS5587783A (en) 1978-12-26 1978-12-26 Hexahydrobenzofuranacetic acid derivative and anti-inflammatory analgesic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16380378A JPS5587783A (en) 1978-12-26 1978-12-26 Hexahydrobenzofuranacetic acid derivative and anti-inflammatory analgesic

Publications (1)

Publication Number Publication Date
JPS5587783A true JPS5587783A (en) 1980-07-02

Family

ID=15780992

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16380378A Pending JPS5587783A (en) 1978-12-26 1978-12-26 Hexahydrobenzofuranacetic acid derivative and anti-inflammatory analgesic

Country Status (1)

Country Link
JP (1) JPS5587783A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI418548B (en) * 2006-04-25 2013-12-11 Merck Patent Gmbh Hexahydrodibenzofuran derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI418548B (en) * 2006-04-25 2013-12-11 Merck Patent Gmbh Hexahydrodibenzofuran derivatives

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