JPS5589267A - New imidazolethiocarboxamide derivative - Google Patents

New imidazolethiocarboxamide derivative

Info

Publication number
JPS5589267A
JPS5589267A JP16431778A JP16431778A JPS5589267A JP S5589267 A JPS5589267 A JP S5589267A JP 16431778 A JP16431778 A JP 16431778A JP 16431778 A JP16431778 A JP 16431778A JP S5589267 A JPS5589267 A JP S5589267A
Authority
JP
Japan
Prior art keywords
derivative
imidazolethiocarboxamide
imidazole
salt
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16431778A
Other languages
Japanese (ja)
Inventor
Yuzo Tarumi
Toshio Atami
Takao Kiyohara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP16431778A priority Critical patent/JPS5589267A/en
Publication of JPS5589267A publication Critical patent/JPS5589267A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:An imidazolethiocarboxamide derivative I (R is H, alkyl, cycloalkyl, 1-adamantyl, unsubstituted or nitro-, halogen- or 1-adamantoyloxy-substituted phenyl) and its salt.
EXAMPLE: 5-Hydroxy-1 H-imidazole-4-thiocarboxamide.
USE: A metabolism-antagonistic substance. Physiological activities, e.g. carcinostatic, antiviral, immunity-enhancing or suppressing, antimicrobial actions, etc. are expected.
PROCESS: A 1H-imidazole-4-carboxamide derivative II is reacted with phosphorus pentasulfide under the solventless condition or in an organic solvent preferably at 50W200°C in the presence of a base to deposit the intermediate III, the salt of the imidazo-oxazaphosphorine derivative with the base. The intermediate is neutralized after or without isolation. The excess amount of an acid is added, and the product is hydrolyzed under reflux for 0.5 to several hours to give the compound I.
COPYRIGHT: (C)1980,JPO&Japio
JP16431778A 1978-12-27 1978-12-27 New imidazolethiocarboxamide derivative Pending JPS5589267A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16431778A JPS5589267A (en) 1978-12-27 1978-12-27 New imidazolethiocarboxamide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16431778A JPS5589267A (en) 1978-12-27 1978-12-27 New imidazolethiocarboxamide derivative

Publications (1)

Publication Number Publication Date
JPS5589267A true JPS5589267A (en) 1980-07-05

Family

ID=15790844

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16431778A Pending JPS5589267A (en) 1978-12-27 1978-12-27 New imidazolethiocarboxamide derivative

Country Status (1)

Country Link
JP (1) JPS5589267A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59167515A (en) * 1983-03-15 1984-09-21 Ajinomoto Co Inc Agent for immunological enhancement

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59167515A (en) * 1983-03-15 1984-09-21 Ajinomoto Co Inc Agent for immunological enhancement

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