JPS5592364A - Disulfide compound - Google Patents

Disulfide compound

Info

Publication number
JPS5592364A
JPS5592364A JP16396478A JP16396478A JPS5592364A JP S5592364 A JPS5592364 A JP S5592364A JP 16396478 A JP16396478 A JP 16396478A JP 16396478 A JP16396478 A JP 16396478A JP S5592364 A JPS5592364 A JP S5592364A
Authority
JP
Japan
Prior art keywords
compound
formula
acetyl
disulfide compound
disulfide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16396478A
Other languages
Japanese (ja)
Other versions
JPS6048511B2 (en
Inventor
Junichi Iwao
Masayuki Ooya
Tadashi Iso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to JP53163964A priority Critical patent/JPS6048511B2/en
Priority to US06/104,970 priority patent/US4347371A/en
Priority to AU54024/79A priority patent/AU536307B2/en
Priority to SE7910554A priority patent/SE446864B/en
Priority to CA342,420A priority patent/CA1128517A/en
Priority to GB7944544A priority patent/GB2042517B/en
Priority to DE19792952594 priority patent/DE2952594A1/en
Priority to IT28440/79A priority patent/IT1127323B/en
Priority to FR7932060A priority patent/FR2445324A1/en
Priority to NL7909334A priority patent/NL7909334A/en
Priority to CH11528/79A priority patent/CH647769A5/en
Priority to ES487373A priority patent/ES8101549A1/en
Priority to AT0820179A priority patent/AT377516B/en
Priority to BE2/58309A priority patent/BE880929A/en
Publication of JPS5592364A publication Critical patent/JPS5592364A/en
Priority to ES494657A priority patent/ES8106497A1/en
Priority to ES494655A priority patent/ES494655A0/en
Priority to ES494656A priority patent/ES8106496A1/en
Priority to ES494654A priority patent/ES8106494A1/en
Priority to US06/186,271 priority patent/US4410542A/en
Publication of JPS6048511B2 publication Critical patent/JPS6048511B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

NEW MATERIAL:A disulfide compound of formula I (Q is methylene or S; R is H or acetyl; A is 2W3C akylene), and its salts.
EXAMPLE: (4R, 4'R)-3,3'-[3, 3'-Dithiobis(propanoyl)] bis [2-(2-hydroxyphenyl)-4- thiazolidine-carboxylic acid].
USE: A hypotensive agent, keeping its effect for a longer term than S-acyl derivatives, without decreasing potency and giving of stench, by he decomposition through formulation processes or with time.
PREPARATION: The compound of formula II is oxidized with air, iodine, ferric chloride, hydrogen peroxide, etc., to obtain the compound of formula I (R=H). The compound of formula I (R is acetyl) is produced by the acetylation of the compound of formula III.
COPYRIGHT: (C)1980,JPO&Japio
JP53163964A 1978-12-30 1978-12-30 disulfide compounds Expired JPS6048511B2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP53163964A JPS6048511B2 (en) 1978-12-30 1978-12-30 disulfide compounds
US06/104,970 US4347371A (en) 1978-12-30 1979-12-18 Disulfide compounds
AU54024/79A AU536307B2 (en) 1978-12-30 1979-12-19 Disulphide derivatives of pyrrolidine and thiazolidine
SE7910554A SE446864B (en) 1978-12-30 1979-12-20 Disulfide compounds, procedure for producing the same and pharmaceutical composition containing said disulfide compounds
CA342,420A CA1128517A (en) 1978-12-30 1979-12-20 Disulfide compounds
FR7932060A FR2445324A1 (en) 1978-12-30 1979-12-28 NOVEL DISULFIDE DERIVATIVES CONTAINING A PYRROLIDINE OR THIAZOLIDINE CYCLE USEFUL AS ANTIHYPERTENSORS AND FOR PREVENTING AND TREATING DIABETES COMPLICATIONS AND METHODS FOR THEIR PREPARATION
BE2/58309A BE880929A (en) 1978-12-30 1979-12-28 DISULFIDE COMPOUNDS
DE19792952594 DE2952594A1 (en) 1978-12-30 1979-12-28 DISULFID COMPOUNDS
IT28440/79A IT1127323B (en) 1978-12-30 1979-12-28 COMPOUNDS CONSTITUTED FROM DISULFURI
GB7944544A GB2042517B (en) 1978-12-30 1979-12-28 Disulphide compounds
NL7909334A NL7909334A (en) 1978-12-30 1979-12-28 METHOD FOR PREPARING A BLOOD PRESSURE REDUCING AGENT BASED ON DISULFIDE COMPOUNDS, THE MEDICINE PREPARED AND A METHOD FOR PREPARING THE ACTIVE COMPONENT.
CH11528/79A CH647769A5 (en) 1978-12-30 1979-12-28 DISULFID COMPOUNDS.
ES487373A ES8101549A1 (en) 1978-12-30 1979-12-28 Process for the preparation of disulpho derivatives
AT0820179A AT377516B (en) 1978-12-30 1979-12-28 METHOD FOR PRODUCING DISULFIDE COMPOUNDS AND THEIR SALTS
ES494657A ES8106497A1 (en) 1978-12-30 1980-08-29 Process for the preparation of disulpho derivatives
ES494654A ES8106494A1 (en) 1978-12-30 1980-08-29 Process for the preparation of disulpho derivatives
ES494655A ES494655A0 (en) 1978-12-30 1980-08-29 A PROCEDURE FOR THE PREPARATION OF DISULFODERIVES
ES494656A ES8106496A1 (en) 1978-12-30 1980-08-29 Process for the preparation of disulpho derivatives
US06/186,271 US4410542A (en) 1978-12-30 1980-09-11 Disulfide compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53163964A JPS6048511B2 (en) 1978-12-30 1978-12-30 disulfide compounds

Publications (2)

Publication Number Publication Date
JPS5592364A true JPS5592364A (en) 1980-07-12
JPS6048511B2 JPS6048511B2 (en) 1985-10-28

Family

ID=15784155

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53163964A Expired JPS6048511B2 (en) 1978-12-30 1978-12-30 disulfide compounds

Country Status (2)

Country Link
JP (1) JPS6048511B2 (en)
BE (1) BE880929A (en)

Also Published As

Publication number Publication date
JPS6048511B2 (en) 1985-10-28
BE880929A (en) 1980-04-16

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