JPS5598113A - Medicinal powder having improved absorbability - Google Patents
Medicinal powder having improved absorbabilityInfo
- Publication number
- JPS5598113A JPS5598113A JP292179A JP292179A JPS5598113A JP S5598113 A JPS5598113 A JP S5598113A JP 292179 A JP292179 A JP 292179A JP 292179 A JP292179 A JP 292179A JP S5598113 A JPS5598113 A JP S5598113A
- Authority
- JP
- Japan
- Prior art keywords
- powder
- drug component
- lymphatic gland
- silica
- micelles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title abstract 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 6
- 229940079593 drug Drugs 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 5
- 210000004907 gland Anatomy 0.000 abstract 4
- 230000001926 lymphatic effect Effects 0.000 abstract 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 239000000377 silicon dioxide Substances 0.000 abstract 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 2
- 239000000693 micelle Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 abstract 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 abstract 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical class C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 abstract 1
- 239000005515 coenzyme Substances 0.000 abstract 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 abstract 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 206010025482 malaise Diseases 0.000 abstract 1
- 229960003512 nicotinic acid Drugs 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229960000984 tocofersolan Drugs 0.000 abstract 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To prepare medicinal powder which can be easily converted to micelles in the digestive tracts even in hungry or in sickness, and has improved absorbability through the lymphatic gland, by covering the surface of silica fine powder with a solid, amorphous, oil-soluble drug component which can be absorbed through the lymphatic gland.
CONSTITUTION: An oil-soluble drug component which is solid at room temperature and absorbable through the lymphatic gland, e.g. coenzyme ubiquinone 10, nicotinic acid dl-α-tocopherol, etc. is dissolved in an organic solvent such as hexane. Fine silica powder is wetted with the solution, and the solvent is removed by heating the mixture at a temperature below the boiling point of the drug component, leaving the drug component as an amorphous layer on the surface of the powder. The weight ratio of the drug to the silica is 1 to 1W15. The composition can be easily converted into micelles in the digestive tracts without adding a surface active agent such as cholic acid salt, etc., and sufficiently high absorbability through the lymphatic gland can be expected.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP292179A JPS5598113A (en) | 1979-01-17 | 1979-01-17 | Medicinal powder having improved absorbability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP292179A JPS5598113A (en) | 1979-01-17 | 1979-01-17 | Medicinal powder having improved absorbability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5598113A true JPS5598113A (en) | 1980-07-25 |
Family
ID=11542807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP292179A Pending JPS5598113A (en) | 1979-01-17 | 1979-01-17 | Medicinal powder having improved absorbability |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5598113A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617294A (en) * | 1985-04-22 | 1986-10-14 | Ppg Industries, Inc. | Animal feed supplement |
| JPH02300123A (en) * | 1989-03-27 | 1990-12-12 | Lederle Japan Ltd | Remedy for peptic ulcer |
| JPH05121040A (en) * | 1991-10-31 | 1993-05-18 | Shimadzu Corp | Mass spectrometer |
| WO2005058281A1 (en) * | 2003-12-17 | 2005-06-30 | Schering Corporation | Hydroxysteroid dehydrogenase inhibitors adsorbed on hydrophilic carriers |
-
1979
- 1979-01-17 JP JP292179A patent/JPS5598113A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617294A (en) * | 1985-04-22 | 1986-10-14 | Ppg Industries, Inc. | Animal feed supplement |
| JPH02300123A (en) * | 1989-03-27 | 1990-12-12 | Lederle Japan Ltd | Remedy for peptic ulcer |
| JPH05121040A (en) * | 1991-10-31 | 1993-05-18 | Shimadzu Corp | Mass spectrometer |
| WO2005058281A1 (en) * | 2003-12-17 | 2005-06-30 | Schering Corporation | Hydroxysteroid dehydrogenase inhibitors adsorbed on hydrophilic carriers |
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