JPS562917A - Stabilization of sulfonated immunoglobulin - Google Patents

Stabilization of sulfonated immunoglobulin

Info

Publication number
JPS562917A
JPS562917A JP7673479A JP7673479A JPS562917A JP S562917 A JPS562917 A JP S562917A JP 7673479 A JP7673479 A JP 7673479A JP 7673479 A JP7673479 A JP 7673479A JP S562917 A JPS562917 A JP S562917A
Authority
JP
Japan
Prior art keywords
sulfonated
stabilization
immoglobulin
stabilize
increase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7673479A
Other languages
Japanese (ja)
Other versions
JPS6220965B2 (en
Inventor
Tsunemasa Yoshida
Shoji Ono
Yuji Fukumoto
Yoshio Ishimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken, Teijin Ltd filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Priority to JP7673479A priority Critical patent/JPS562917A/en
Publication of JPS562917A publication Critical patent/JPS562917A/en
Publication of JPS6220965B2 publication Critical patent/JPS6220965B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: To stabilize the title sulfonated immoglobulin (S), by adding serum albumin etc. to S as a stabilizer.
CONSTITUTION: 0.01W1.0pt.wt of serum albumin, and if necessary 0.2W1.0pt.wt. of glycine and/or 0.04wt% of mannitol, are added to stabilize 1pt.wt. of sulfonated immoglobulin. The method prevents the problems of increase in aggregates in dialysis, transportation and freeze-drying steps by the mechanical or thermal denaturation or opacifying of a solution leading to the increase in anticomplementary value of the final product.
COPYRIGHT: (C)1981,JPO&Japio
JP7673479A 1979-06-20 1979-06-20 Stabilization of sulfonated immunoglobulin Granted JPS562917A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7673479A JPS562917A (en) 1979-06-20 1979-06-20 Stabilization of sulfonated immunoglobulin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7673479A JPS562917A (en) 1979-06-20 1979-06-20 Stabilization of sulfonated immunoglobulin

Publications (2)

Publication Number Publication Date
JPS562917A true JPS562917A (en) 1981-01-13
JPS6220965B2 JPS6220965B2 (en) 1987-05-11

Family

ID=13613808

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7673479A Granted JPS562917A (en) 1979-06-20 1979-06-20 Stabilization of sulfonated immunoglobulin

Country Status (1)

Country Link
JP (1) JPS562917A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58192830A (en) * 1982-05-04 1983-11-10 Teijin Ltd Remedy for thrombocytopenia
US6165467A (en) * 1991-07-20 2000-12-26 Yoshihide Hagiwara Stabilized human monoclonal antibody preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58192830A (en) * 1982-05-04 1983-11-10 Teijin Ltd Remedy for thrombocytopenia
US6165467A (en) * 1991-07-20 2000-12-26 Yoshihide Hagiwara Stabilized human monoclonal antibody preparation

Also Published As

Publication number Publication date
JPS6220965B2 (en) 1987-05-11

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