JPS5632442A - Polyprenylcarboxylic acid amide - Google Patents
Polyprenylcarboxylic acid amideInfo
- Publication number
- JPS5632442A JPS5632442A JP10866879A JP10866879A JPS5632442A JP S5632442 A JPS5632442 A JP S5632442A JP 10866879 A JP10866879 A JP 10866879A JP 10866879 A JP10866879 A JP 10866879A JP S5632442 A JPS5632442 A JP S5632442A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reagent
- wittig
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001408 amides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 208000019423 liver disease Diseases 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:Title compounds of formula I (n is integer of 1W4; a, b are H or a bond between a and b is formed; R1, R2 are H, lower alkyl, phenyl, or they may form 5- or 6-membered heterocyclic ring together with the adjacent nitrogen atom).
EXAMPLE: 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraene amide.
USE: Treatment for hepatic disorders: they are of low toxicity and show ameliorative and pyrophylactic effects on hepatic disorders.
PREPARATION: The Wittig's reagent that is derived from a compound of formula III (X is halogen) is made to act on a compound of formula II to give the compound of formula I. The Wittig's reagent is, e.g., a compound of formula IV (R is alkyl), which is derived from a compound of formula III and trialkyl phosphite. In the reaction, a basic reagent such as butyllithium is added in general.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10866879A JPS5632442A (en) | 1979-08-28 | 1979-08-28 | Polyprenylcarboxylic acid amide |
| PH24388A PH16234A (en) | 1979-08-14 | 1980-08-04 | Polyphenylcarboxylic acid amides |
| US06/175,213 US4456603A (en) | 1979-08-14 | 1980-08-04 | Polyprenylcarboxylic acid amides useful for treating liver dysfunction |
| CH598880A CH644582A5 (en) | 1979-08-14 | 1980-08-07 | POLYPRENYLCARBOXYLIC ACID AMIDES. |
| AU61342/80A AU531466B2 (en) | 1979-08-14 | 1980-08-11 | Acid amides |
| GB8026161A GB2058782B (en) | 1979-08-14 | 1980-08-12 | Polyprenylcarboxylic acid amides |
| DE19803030462 DE3030462A1 (en) | 1979-08-14 | 1980-08-12 | POLYPRENYL CARBONIC ACID AMIDES, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND |
| FR8017742A FR2463122A1 (en) | 1979-08-14 | 1980-08-12 | POLYPRENYLCARBOXYLIC AMIDES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED ON SAID AMIDE |
| ES494230A ES494230A0 (en) | 1979-08-14 | 1980-08-13 | A PROCEDURE FOR THE PREPARATION OF AMIDES OF PO-LIPRENILCARBOXILICO ACID |
| SE8005712A SE446977B (en) | 1979-08-14 | 1980-08-13 | POLYPRENYL CARBOXYLIC ACAMAMIDS, THE PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
| NL8004609A NL8004609A (en) | 1979-08-14 | 1980-08-14 | CARBONIC ACID AMIDS AND PHARMACEUTICAL PREPARATION AND METHOD FOR PREPARING THEREOF. |
| IT24157/80A IT1132406B (en) | 1979-08-14 | 1980-08-14 | POLYPRENYLCARBOXYLIC ACID AMID |
| CA000358233A CA1148153A (en) | 1979-08-14 | 1980-08-14 | Polyprenylcarboxylic acid amides |
| FR8122993A FR2497802A1 (en) | 1979-08-14 | 1981-12-09 | NOVEL POLYPRENYLCARBOXYL AMIDES, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION BASED ON SAID AMIDE |
| SE8404308A SE8404308L (en) | 1979-08-14 | 1984-08-29 | POLYPRENYL CARBOXYLIC ACAMAMIDS, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
| US06/677,893 US4639450A (en) | 1979-08-14 | 1984-12-04 | Polyprenylcarboxylic acid morpholides and pharmaceutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10866879A JPS5632442A (en) | 1979-08-28 | 1979-08-28 | Polyprenylcarboxylic acid amide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5632442A true JPS5632442A (en) | 1981-04-01 |
| JPS6251263B2 JPS6251263B2 (en) | 1987-10-29 |
Family
ID=14490643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10866879A Granted JPS5632442A (en) | 1979-08-14 | 1979-08-28 | Polyprenylcarboxylic acid amide |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5632442A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020171210A1 (en) * | 2019-02-21 | 2020-08-27 | 株式会社萩原農場生産研究所 | Cancer cell growth inhibiting composition and processed food |
-
1979
- 1979-08-28 JP JP10866879A patent/JPS5632442A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020171210A1 (en) * | 2019-02-21 | 2020-08-27 | 株式会社萩原農場生産研究所 | Cancer cell growth inhibiting composition and processed food |
| US12338198B2 (en) | 2019-02-21 | 2025-06-24 | Hagihara Farm Production Institute Co., Ltd. | Cancer cell growth inhibiting composition and processed food |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6251263B2 (en) | 1987-10-29 |
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