JPS5632474A - Piperazine derivative and its preparation - Google Patents

Piperazine derivative and its preparation

Info

Publication number
JPS5632474A
JPS5632474A JP11529680A JP11529680A JPS5632474A JP S5632474 A JPS5632474 A JP S5632474A JP 11529680 A JP11529680 A JP 11529680A JP 11529680 A JP11529680 A JP 11529680A JP S5632474 A JPS5632474 A JP S5632474A
Authority
JP
Japan
Prior art keywords
compound
formula
group
piperazine derivative
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11529680A
Other languages
Japanese (ja)
Inventor
Tsutomu Terachi
Teruo Oku
Takayuki Namiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS5632474A publication Critical patent/JPS5632474A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A piperazine derivative of formula I [R1 is carboxy(derivative), oxalo or acylamino group; R2 is H, halogen, alkyl, alkoxy, aryl or acylamino group; R3 is aralkyl group; A is alkylene group; X is NR4 (R4 is H or acyl group), O, S or NHCO], and a pharmaceutically acceptable salt thereof.
EXAMPLE: N-[3-(4-Benzhydryl-1-piperazinyl)propyl]-4-fluoroanthranilic acid.
USE: An antiallergic agent for treating an allergic disorder of men and animals.
PROCESS: A compound of formula II or a salt thereof is reacted with a compound of formula III, preferably in the presence of a base or an iodine compound, to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP11529680A 1979-08-21 1980-08-20 Piperazine derivative and its preparation Pending JPS5632474A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7929092A GB2056968A (en) 1979-08-21 1979-08-21 Piperazine derivative, processes for the preparation thereof and pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
JPS5632474A true JPS5632474A (en) 1981-04-01

Family

ID=10507336

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11529680A Pending JPS5632474A (en) 1979-08-21 1980-08-20 Piperazine derivative and its preparation

Country Status (2)

Country Link
JP (1) JPS5632474A (en)
GB (1) GB2056968A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5987578U (en) * 1983-11-10 1984-06-13 エヌ・ベ−・フイリツプス・フル−イランペンフアブリケン heat exchange ventilation equipment

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6025958A (en) * 1983-07-21 1985-02-08 Kowa Co Novel aminoalkyl-substituted benzene derivative
IT1190375B (en) * 1985-06-20 1988-02-16 Recordati Chem Pharm N-BENZHYDRYDIAZACYCLALCHYL-ALCANYLIDES WITH ANTIANAPHYLACTIC AND ANTIBRONCOSPASTIC ACTIVITY
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
TW198008B (en) * 1991-04-08 1993-01-11 Green Cross Corp
WO1993002062A1 (en) * 1991-07-19 1993-02-04 Zeria Pharmaceutical Co., Ltd. Piperazine derivative and drug containing the same
ATE159715T1 (en) * 1992-07-20 1997-11-15 Eisai Co Ltd BENZOLE DERIVATIVES
US6906192B2 (en) 2000-11-07 2005-06-14 Bristol Myers Squibb Company Processes for the preparation of acid derivatives useful as serine protease inhibitors
EP1332131A2 (en) 2000-11-07 2003-08-06 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
US7985763B2 (en) 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
US7897764B2 (en) * 2007-06-08 2011-03-01 National Health Research Institutes Thiourea derivatives
US8198284B2 (en) 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5987578U (en) * 1983-11-10 1984-06-13 エヌ・ベ−・フイリツプス・フル−イランペンフアブリケン heat exchange ventilation equipment

Also Published As

Publication number Publication date
GB2056968A (en) 1981-03-25

Similar Documents

Publication Publication Date Title
ATE133667T1 (en) THIAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JPS5632474A (en) Piperazine derivative and its preparation
IL57577A0 (en) 1,2-dihydroquinolin-2-one derivatives,process for their preparation and pharmaceutical compositions containing the same
ES8400393A1 (en) Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions.
JPS56103168A (en) Thiazole derivative, its preparation, and antihistaminic agent containing the same
JPS54128588A (en) Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline
ES8407463A1 (en) Arylethanol amine derivatives, their preparation and use in pharmaceutical compositions.
JPS51118772A (en) Method for preparing carbostyryl derivatives
JPS56142282A (en) Penem-3-carboxylic acid derivative and its preparation
JPS5697268A (en) Lower alkanoic acid derivative, salt and preparation thereof and preventing agent and remedy for diabetic complication containing the same as active constituent
ES8106147A1 (en) 1,2,4-Triazole-3-thiols as antisecretory agents
JPS54160381A (en) Tetrazolylcoumarin
JPS55111447A (en) Novel 3-amino-4-homoisotwistane derivative
JPS5594382A (en) Chroman-based compound and cholestrol lowering drug comprising it
JPS5711975A (en) Aminophenyltetrazole derivative and salt thereof
SE7905025L (en) TEREFTALIC ACID MONOAMIDE DERIVATIVE, PROCEDURE FOR THE PREPARATION AND ANTIALLERGIC
JPS56142283A (en) Penem-3-carboxylic acid derivative and its preparation
JPS55130961A (en) N-quinolyloxamic acid derivative and antiallergic remedy for asthma
JPS55129275A (en) Farnesylacetic acid amide bearing piperazine ring or its salt
JPS567762A (en) Acylated indole derivative, its preparation, and platelet coagulation inhibiting agent containing the same
JPS51125087A (en) A process for preparing novel acylhydrazone derivatives and their salt s
JPS51115918A (en) Germicides for the porposes withowt medical treatment and method for p reparing them
JPS5636414A (en) Anticonvulsant agent containing omega-aminoalkoxystilbene or its acid addition salt as active constituent
JPS54103879A (en) Novel penicillamine
JPS5645499A (en) Glucosamine derivative and its preparation