JPS565415A - Ester-type hypotensor - Google Patents

Ester-type hypotensor

Info

Publication number
JPS565415A
JPS565415A JP8104379A JP8104379A JPS565415A JP S565415 A JPS565415 A JP S565415A JP 8104379 A JP8104379 A JP 8104379A JP 8104379 A JP8104379 A JP 8104379A JP S565415 A JPS565415 A JP S565415A
Authority
JP
Japan
Prior art keywords
formula
compound
hypotensor
lower alkyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8104379A
Other languages
Japanese (ja)
Other versions
JPS6313993B2 (en
Inventor
Junichi Iwao
Masayuki Ooya
Tadashi Iso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to JP8104379A priority Critical patent/JPS565415A/en
Priority to US06/104,970 priority patent/US4347371A/en
Priority to AU54024/79A priority patent/AU536307B2/en
Priority to SE7910554A priority patent/SE446864B/en
Priority to CA342,420A priority patent/CA1128517A/en
Priority to CH11528/79A priority patent/CH647769A5/en
Priority to FR7932060A priority patent/FR2445324A1/en
Priority to NL7909334A priority patent/NL7909334A/en
Priority to DE19792952594 priority patent/DE2952594A1/en
Priority to GB7944544A priority patent/GB2042517B/en
Priority to ES487373A priority patent/ES8101549A1/en
Priority to AT0820179A priority patent/AT377516B/en
Priority to IT28440/79A priority patent/IT1127323B/en
Priority to ES494655A priority patent/ES494655A0/en
Priority to ES494657A priority patent/ES494657A0/en
Priority to ES494654A priority patent/ES494654A0/en
Priority to ES494656A priority patent/ES494656A0/en
Priority to US06/186,271 priority patent/US4410542A/en
Publication of JPS565415A publication Critical patent/JPS565415A/en
Publication of JPS6313993B2 publication Critical patent/JPS6313993B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A thiazolidine derivative or a pyrrolidine derivative of formula I (Q is methylene or S; R1 is H, alkyl, cycloalkyl, etc.; R2 is lower alkyl, acyloxy lower alkyl, etc.; A is 1W3C alkylene).
EXAMPLE: (4R,4'R)-3,3'-[ 3,3'-Dithiobis(propanoyl) ]bis[ 2-(2-hydroxyphenyl)-4- thiazolidinecarboxylic acid (1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl ester.
USE: Hypotensor having high oleophilic properties, improved absorption characteristics, and long effective period, compared with free mercaptoacylamino acid.
PROCESS: The compound of formula I is prepared by reacting a compound of formula II with a compound of formula III (X is halogen).
COPYRIGHT: (C)1981,JPO&Japio
JP8104379A 1978-12-30 1979-06-26 Ester-type hypotensor Granted JPS565415A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP8104379A JPS565415A (en) 1979-06-26 1979-06-26 Ester-type hypotensor
US06/104,970 US4347371A (en) 1978-12-30 1979-12-18 Disulfide compounds
AU54024/79A AU536307B2 (en) 1978-12-30 1979-12-19 Disulphide derivatives of pyrrolidine and thiazolidine
SE7910554A SE446864B (en) 1978-12-30 1979-12-20 Disulfide compounds, procedure for producing the same and pharmaceutical composition containing said disulfide compounds
CA342,420A CA1128517A (en) 1978-12-30 1979-12-20 Disulfide compounds
CH11528/79A CH647769A5 (en) 1978-12-30 1979-12-28 DISULFID COMPOUNDS.
FR7932060A FR2445324A1 (en) 1978-12-30 1979-12-28 NOVEL DISULFIDE DERIVATIVES CONTAINING A PYRROLIDINE OR THIAZOLIDINE CYCLE USEFUL AS ANTIHYPERTENSORS AND FOR PREVENTING AND TREATING DIABETES COMPLICATIONS AND METHODS FOR THEIR PREPARATION
NL7909334A NL7909334A (en) 1978-12-30 1979-12-28 METHOD FOR PREPARING A BLOOD PRESSURE REDUCING AGENT BASED ON DISULFIDE COMPOUNDS, THE MEDICINE PREPARED AND A METHOD FOR PREPARING THE ACTIVE COMPONENT.
DE19792952594 DE2952594A1 (en) 1978-12-30 1979-12-28 DISULFID COMPOUNDS
GB7944544A GB2042517B (en) 1978-12-30 1979-12-28 Disulphide compounds
ES487373A ES8101549A1 (en) 1978-12-30 1979-12-28 Process for the preparation of disulpho derivatives
AT0820179A AT377516B (en) 1978-12-30 1979-12-28 METHOD FOR PRODUCING DISULFIDE COMPOUNDS AND THEIR SALTS
IT28440/79A IT1127323B (en) 1978-12-30 1979-12-28 COMPOUNDS CONSTITUTED FROM DISULFURI
ES494655A ES494655A0 (en) 1978-12-30 1980-08-29 A PROCEDURE FOR THE PREPARATION OF DISULFODERIVES
ES494657A ES494657A0 (en) 1978-12-30 1980-08-29 A PROCEDURE FOR THE PREPARATION OF DISULFODERIVES
ES494654A ES494654A0 (en) 1978-12-30 1980-08-29 A PROCEDURE FOR THE PREPARATION OF DIFFERENCES
ES494656A ES494656A0 (en) 1978-12-30 1980-08-29 A PROCEDURE FOR THE PREPARATION OF DIFFERENCES
US06/186,271 US4410542A (en) 1978-12-30 1980-09-11 Disulfide compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8104379A JPS565415A (en) 1979-06-26 1979-06-26 Ester-type hypotensor

Publications (2)

Publication Number Publication Date
JPS565415A true JPS565415A (en) 1981-01-20
JPS6313993B2 JPS6313993B2 (en) 1988-03-29

Family

ID=13735401

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8104379A Granted JPS565415A (en) 1978-12-30 1979-06-26 Ester-type hypotensor

Country Status (1)

Country Link
JP (1) JPS565415A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5382778A (en) * 1976-12-03 1978-07-21 Squibb & Sons Inc Thiazolidinecarboxylate derivative and related compounds thereof process for preparing same and application thereof
JPS5432466A (en) * 1977-08-15 1979-03-09 Yoshitomi Pharmaceut Ind Ltd Thiazolidine derivatives and their preparation
JPS5466675A (en) * 1977-09-28 1979-05-29 Science Union & Cie Omegaamercaptopropionamido*its manufacture and medical composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5382778A (en) * 1976-12-03 1978-07-21 Squibb & Sons Inc Thiazolidinecarboxylate derivative and related compounds thereof process for preparing same and application thereof
JPS5432466A (en) * 1977-08-15 1979-03-09 Yoshitomi Pharmaceut Ind Ltd Thiazolidine derivatives and their preparation
JPS5466675A (en) * 1977-09-28 1979-05-29 Science Union & Cie Omegaamercaptopropionamido*its manufacture and medical composition

Also Published As

Publication number Publication date
JPS6313993B2 (en) 1988-03-29

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