JPS565456A - Prostacycline derivative - Google Patents
Prostacycline derivativeInfo
- Publication number
- JPS565456A JPS565456A JP8087079A JP8087079A JPS565456A JP S565456 A JPS565456 A JP S565456A JP 8087079 A JP8087079 A JP 8087079A JP 8087079 A JP8087079 A JP 8087079A JP S565456 A JPS565456 A JP S565456A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- prostacycline
- compound shown
- pge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical class O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 abstract 2
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 239000003130 blood coagulation factor inhibitor Substances 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- KAQKFAOMNZTLHT-OZUDYXHBSA-N prostaglandin I2 Chemical compound O1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-OZUDYXHBSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A prostacycline derivative shown by the formula I (R1 is alkyl or alkenyl; R2 is alkyl or ethynyl; or both R1 and R2 are H; m is integer of 0W5; n is integer of 0W3; Y is direct bond, trans-vinylene, etc.) its salt, and its alkyl ester.
EXAMPLE: 5,8α-Methylene-10α,14-dihydroxy-14-methylnorprost-4,12(E)-dienoic acid.
USE: A blood platelet coagulation inhibitor. Having almost the same activity as that of PGE1(prostaglandine E1), but stabler than PGE1 and PGI2(prostacycline I2).
PROCESS: A compound shown by the formula II (R1' is alkyl, etc.) is oxidized with DDQ(dichlorodycianobenzoquinone), etc. to give a compound shown by the formula III. COOH or OH group of the compound is protected, if necessary. It is alkylated by a Grignard reagent, or subjected to ethynylation, and, the protecting group is removed, to give the compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8087079A JPS565456A (en) | 1979-06-27 | 1979-06-27 | Prostacycline derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8087079A JPS565456A (en) | 1979-06-27 | 1979-06-27 | Prostacycline derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS565456A true JPS565456A (en) | 1981-01-20 |
| JPS6340175B2 JPS6340175B2 (en) | 1988-08-10 |
Family
ID=13730370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8087079A Granted JPS565456A (en) | 1979-06-27 | 1979-06-27 | Prostacycline derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS565456A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60206882A (en) * | 1984-03-30 | 1985-10-18 | Sunstar Giken Kk | Epoxy resin adhesive |
| JPS60235877A (en) * | 1984-05-08 | 1985-11-22 | Sunstar Giken Kk | Epoxy resin adhesive for automobile |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100193572B1 (en) * | 1995-06-30 | 1999-06-15 | 이형도 | Breathless DC Motor |
-
1979
- 1979-06-27 JP JP8087079A patent/JPS565456A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60206882A (en) * | 1984-03-30 | 1985-10-18 | Sunstar Giken Kk | Epoxy resin adhesive |
| JPS60235877A (en) * | 1984-05-08 | 1985-11-22 | Sunstar Giken Kk | Epoxy resin adhesive for automobile |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6340175B2 (en) | 1988-08-10 |
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