JPS565485A - Cephalosporin derivative and its salt - Google Patents

Cephalosporin derivative and its salt

Info

Publication number
JPS565485A
JPS565485A JP8170279A JP8170279A JPS565485A JP S565485 A JPS565485 A JP S565485A JP 8170279 A JP8170279 A JP 8170279A JP 8170279 A JP8170279 A JP 8170279A JP S565485 A JPS565485 A JP S565485A
Authority
JP
Japan
Prior art keywords
formula
salt
cephalosporin
formyl
sodium salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8170279A
Other languages
Japanese (ja)
Inventor
Junji Nakano
Toshio Furumiya
Yoshiyuki Takase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP8170279A priority Critical patent/JPS565485A/en
Publication of JPS565485A publication Critical patent/JPS565485A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A cephalosporin derivative of formula I (R is formyl or acetyl group; R' is acetoxy group, etc.), and its salt.
EXAMPLE: 7-[ D-α-[ 1, 4-Dihydro-7-( 4-formyl-1-piperazinyl )-4-oxo-1, 8-naphthyridine-3-carboxamido ]-α-p-hydroxyphenylacetamido ]-3-( 1-carboxymethyltetrazol- 5-yl)-thiomethyl-3-cephem-4-carboxylic aicd sodium salt.
USE: An antimicrobial and its intermediate effective against Gram-positive and Gram- negative bacteria, particularly Pseudomonas aeruginosa, with low toxicity and high solubility.
PROCESS: A carboxylic acid of formula II or its reactive derivative at the carboxyl group, e.g. an acid halide or active ester, is reacted with a cephalosporin of formula III or its reactive derivative, e.g. sodium salt, to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP8170279A 1979-06-27 1979-06-27 Cephalosporin derivative and its salt Pending JPS565485A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8170279A JPS565485A (en) 1979-06-27 1979-06-27 Cephalosporin derivative and its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8170279A JPS565485A (en) 1979-06-27 1979-06-27 Cephalosporin derivative and its salt

Publications (1)

Publication Number Publication Date
JPS565485A true JPS565485A (en) 1981-01-20

Family

ID=13753706

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8170279A Pending JPS565485A (en) 1979-06-27 1979-06-27 Cephalosporin derivative and its salt

Country Status (1)

Country Link
JP (1) JPS565485A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004595A1 (en) * 1988-10-24 1990-05-03 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial fluoroquinolonyl cephems

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004595A1 (en) * 1988-10-24 1990-05-03 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial fluoroquinolonyl cephems

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