JPS565488A - Isothiazolobenzisothiazolium salt and its preparation - Google Patents
Isothiazolobenzisothiazolium salt and its preparationInfo
- Publication number
- JPS565488A JPS565488A JP7942079A JP7942079A JPS565488A JP S565488 A JPS565488 A JP S565488A JP 7942079 A JP7942079 A JP 7942079A JP 7942079 A JP7942079 A JP 7942079A JP S565488 A JPS565488 A JP S565488A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- acid
- benzothiazocine
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BQOZFAWKIFDTLA-UHFFFAOYSA-N [1,2]thiazolo[5,4-e][2,1]benzothiazole Chemical class S1N=CC2=C1C=1C(C=C2)=NSC=1 BQOZFAWKIFDTLA-UHFFFAOYSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 2, 3-Dihydro-7-methyl-1H, 5H-isothiazolo[ 2, 1-a ][ 2, 1 ]benzoisothiazolium chloride Chemical compound 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- SJIUDSMSYHUFGC-UHFFFAOYSA-N 2h-1$l^{4},2-benzothiazocine 1-oxide Chemical compound O=S1NC=CC=CC2=CC=CC=C12 SJIUDSMSYHUFGC-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound of formula I (R1 and R2 are H or lower alkyl groups; X1 and X2 are H, lower alkyl, lower alkoxy groups, etc.; Y is acid residue).
EXAMPLE: 2, 3-Dihydro-7-methyl-1H, 5H-isothiazolo[ 2, 1-a ][ 2, 1 ]benzoisothiazolium chloride.
USE: A drug for peptic ulcer having a gastric secretion suppressing action and an intermediate for the synthesis of a benzothiazocine-S-oxide compound having the powerful action.
PROCESS: A benzothiazocine-S-oxide compound of formula II is reacted with an acid, e.g. a mineral acid such as hydrochloric, nitric or sulfuric acid, in a solvent, e.g. methanol, at room temperature for 5minW1hr to give the compound of formula I. The resulting compound can be converted into the compound of formula II by treating with a base, e.g. NaOH or KOH.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7942079A JPS565488A (en) | 1979-06-23 | 1979-06-23 | Isothiazolobenzisothiazolium salt and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7942079A JPS565488A (en) | 1979-06-23 | 1979-06-23 | Isothiazolobenzisothiazolium salt and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS565488A true JPS565488A (en) | 1981-01-20 |
Family
ID=13689364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7942079A Pending JPS565488A (en) | 1979-06-23 | 1979-06-23 | Isothiazolobenzisothiazolium salt and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS565488A (en) |
-
1979
- 1979-06-23 JP JP7942079A patent/JPS565488A/en active Pending
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