JPS5667301A - Sulfated polysaccharide - Google Patents
Sulfated polysaccharideInfo
- Publication number
- JPS5667301A JPS5667301A JP14489579A JP14489579A JPS5667301A JP S5667301 A JPS5667301 A JP S5667301A JP 14489579 A JP14489579 A JP 14489579A JP 14489579 A JP14489579 A JP 14489579A JP S5667301 A JPS5667301 A JP S5667301A
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- sulfated polysaccharide
- ph6w8
- erythrocite
- micrococci
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004676 glycans Chemical class 0.000 title abstract 2
- 229920001282 polysaccharide Polymers 0.000 title abstract 2
- 239000005017 polysaccharide Substances 0.000 title abstract 2
- 239000000463 material Substances 0.000 abstract 3
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 abstract 1
- 108010013639 Peptidoglycan Proteins 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 238000000921 elemental analysis Methods 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
NEW MATERIAL:Sulfated polysaccharide DF-4639 having a glucide portion consisting mainly of D-glucose and D-galactose, to which is bonded a peptidoglycan portion and having the following properties: average MW about 23,000 (gel filtration method); elemental analysis: C26.20W26.90%, H3.77W3.96%, N0.71W1.18%, S10.7W11.6%, P0.75W1.02%, sugar content:56.4%; protein content:2.0%; specific rotatory power: [d]D25-36±1° (1% aqueous solution); major absorption hand in infrared absorption spectrum (cm-1, KBr): 1,240, 840 (shoulder), 800W820; solubility:readily soluble in water, practically insoluble in an organic solvent; basicity, neutrality or acidity:pH6W8 (3% aqueous solution of the Na salt).
USE: Antithrombotic agent. The material shows weaker anticoagulant activity than heparin, and does not show erythrocite agglutination-promoting action.
PREPARATION: Micrococci AT-25 (FERM-P52355) are cultured. Then, the material DF-4639 is collected from the culture.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14489579A JPS5667301A (en) | 1979-11-08 | 1979-11-08 | Sulfated polysaccharide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14489579A JPS5667301A (en) | 1979-11-08 | 1979-11-08 | Sulfated polysaccharide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8371088A Division JPS63273471A (en) | 1988-04-05 | 1988-04-05 | Microbial strain at-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5667301A true JPS5667301A (en) | 1981-06-06 |
| JPH0144721B2 JPH0144721B2 (en) | 1989-09-29 |
Family
ID=15372824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14489579A Granted JPS5667301A (en) | 1979-11-08 | 1979-11-08 | Sulfated polysaccharide |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5667301A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900815A (en) * | 1986-05-23 | 1990-02-13 | Daiichi Seiyaku Co., Ltd. | Sulfated polysaccharide DS4152 |
| CN104631168A (en) * | 2015-01-28 | 2015-05-20 | 广西壮族自治区中国科学院广西植物研究所 | Application of wet stacking in keeping hemicellulose with macromolecular structure characteristics in straw and straw storage method |
-
1979
- 1979-11-08 JP JP14489579A patent/JPS5667301A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900815A (en) * | 1986-05-23 | 1990-02-13 | Daiichi Seiyaku Co., Ltd. | Sulfated polysaccharide DS4152 |
| CN104631168A (en) * | 2015-01-28 | 2015-05-20 | 广西壮族自治区中国科学院广西植物研究所 | Application of wet stacking in keeping hemicellulose with macromolecular structure characteristics in straw and straw storage method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0144721B2 (en) | 1989-09-29 |
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