JPS5671096A - 2-phenylimidazo 2,1-b- benzothiazole derivative - Google Patents
2-phenylimidazo 2,1-b- benzothiazole derivativeInfo
- Publication number
- JPS5671096A JPS5671096A JP14844179A JP14844179A JPS5671096A JP S5671096 A JPS5671096 A JP S5671096A JP 14844179 A JP14844179 A JP 14844179A JP 14844179 A JP14844179 A JP 14844179A JP S5671096 A JPS5671096 A JP S5671096A
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- double bond
- dotted line
- lower alkyl
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 e.g. Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000000018 nitroso group Chemical group N(=O)* 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound shown by the formula I [R1W3 is H, halogen, lower alkyl, OH, etc.; X is halogen, nitroso, nitro, etc.; dotted line is (nonexisting) double bond; any adjoining two of R1W3 may form benzene ring; with the proviso that when X is bromine and R2W3 are H and the dotted line is double bond, R1 is lower alkyl, OH, lower alkoxy, etc.; when X is nitroso or nitro, R2W3 are H, and the dotted line is double bond, R1 is halogen, lower alkyl, OH, phenyl lower alkoxy, etc.].
USE: An antiallergic agent, antiasthmatic, antirheumatic, anti-inglammatory agent, carcinostatic substance, and autoimmune disease.
PROCESS: A compound shown by the formula II is halogenated conventionally with a halogenating agent, e.g., Cl, Br, sulfuryl chloride in an organic solvent, e.g., methylene chloride or a water-containing organic solvent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14844179A JPS5671096A (en) | 1979-11-16 | 1979-11-16 | 2-phenylimidazo 2,1-b- benzothiazole derivative |
| FR8017896A FR2463774A1 (en) | 1979-08-21 | 1980-08-13 | DERIVATIVES OF 2-PHENYLIMIDAZO (2,1-B) BENZOTHIAZOLE |
| DE19803030982 DE3030982A1 (en) | 1979-08-21 | 1980-08-16 | 2-PHENYLIMIDAZO (2,1-B) BENZOTHIAZOLE DERIVATIVES |
| ES494397A ES494397A0 (en) | 1979-08-21 | 1980-08-20 | A PRODUCTION PROCEDURE OF A 2-PHENYLIMI-DAZO (2,1-B) BENZOTIAZOLE DERIVATIVE |
| IT68303/80A IT1166483B (en) | 1979-08-21 | 1980-08-20 | DERIVATIVES OF 2 FENYLIMIDAZO 2 1 B BENZOTHIAZOLE HAVING AN IMMUNOREGULATORY EFFECT AND PROCEDURE FOR THEIR PREPARATION |
| AT0425280A ATA425280A (en) | 1979-08-21 | 1980-08-20 | METHOD FOR PRODUCING NEW 2-PHENYL-IMIDAZO (2.1-B) -BENZOTHIAZOLE DERIVATIVES |
| GB8027243A GB2056982B (en) | 1979-08-21 | 1980-08-21 | 2 - phenylimidazo(2,1 - b)benzothiazole derivatives |
| CA000358790A CA1158246A (en) | 1979-08-21 | 1980-08-21 | Process of producing 2-phenylimidazo¬2,1-b| benzothiazole derivatives |
| US06/487,357 US4497817A (en) | 1979-08-21 | 1983-04-26 | 2-Phenylimidazo [2,1-b]benzothiazole derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14844179A JPS5671096A (en) | 1979-11-16 | 1979-11-16 | 2-phenylimidazo 2,1-b- benzothiazole derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5671096A true JPS5671096A (en) | 1981-06-13 |
| JPS6320237B2 JPS6320237B2 (en) | 1988-04-26 |
Family
ID=15452860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14844179A Granted JPS5671096A (en) | 1979-08-21 | 1979-11-16 | 2-phenylimidazo 2,1-b- benzothiazole derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5671096A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968708A (en) * | 1988-06-22 | 1990-11-06 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same |
-
1979
- 1979-11-16 JP JP14844179A patent/JPS5671096A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968708A (en) * | 1988-06-22 | 1990-11-06 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6320237B2 (en) | 1988-04-26 |
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