JPS5676401A - Simple glucan separated from cultured choray, preparation thereof and antitumor agent containing its polysaccharide as effective component - Google Patents
Simple glucan separated from cultured choray, preparation thereof and antitumor agent containing its polysaccharide as effective componentInfo
- Publication number
- JPS5676401A JPS5676401A JP15315979A JP15315979A JPS5676401A JP S5676401 A JPS5676401 A JP S5676401A JP 15315979 A JP15315979 A JP 15315979A JP 15315979 A JP15315979 A JP 15315979A JP S5676401 A JPS5676401 A JP S5676401A
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- glucan
- choray
- preparation
- antitumor agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000004676 glycans Chemical class 0.000 title abstract 5
- 229920001282 polysaccharide Polymers 0.000 title abstract 5
- 239000005017 polysaccharide Substances 0.000 title abstract 5
- 229920001503 Glucan Polymers 0.000 title abstract 3
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000221198 Basidiomycota Species 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000007105 physical stamina Effects 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
NEW MATERIAL:Titled simple glucan wherein two to three β-1,6-bonded glucose molecules are bonded to the main chain by β-1,6-bond per two β-1,3-glucoxide- bonded glucose units constituting the main chain.
USE: Antitumor agent, prophilactic against infectious diseases such as hepatitis and pneumonia, caused by viral or bacterial infection resulting from the decline of physical stamina or immunity strength.
PREPARATION: Cultured mycelia of Choray Basidiomycetes [FERM-P5237(GU- 10)] are extracted with hot water. The extract is purified and concentrated by filtration, dialysis, etc., and mixed with a precipitant such as ethanol thereby to yield crude polysaccharide. Then, to the crude polysaccharide is added a quat. ammonium salt to precipitate impurities. To the resulting supernatant liquid is added a precipitant to precipitate purified polysaccharide. Next, this purified polysaccharide is dissolved in water and fractionated, for example, by gel filtration to yield simple glucan having the structure represented by the formula.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15315979A JPS5676401A (en) | 1979-11-27 | 1979-11-27 | Simple glucan separated from cultured choray, preparation thereof and antitumor agent containing its polysaccharide as effective component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15315979A JPS5676401A (en) | 1979-11-27 | 1979-11-27 | Simple glucan separated from cultured choray, preparation thereof and antitumor agent containing its polysaccharide as effective component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5676401A true JPS5676401A (en) | 1981-06-24 |
Family
ID=15556317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15315979A Pending JPS5676401A (en) | 1979-11-27 | 1979-11-27 | Simple glucan separated from cultured choray, preparation thereof and antitumor agent containing its polysaccharide as effective component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5676401A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU647751B2 (en) * | 1989-09-08 | 1994-03-31 | Alpha-Beta Technology, Inc. | Method for immune system activation |
| US5322841A (en) * | 1989-09-08 | 1994-06-21 | Alpha-Beta Technology, Inc. | Method for producing neutral glucans for pharmaceutical applications |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| US5633369A (en) * | 1989-09-08 | 1997-05-27 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US6046323A (en) * | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
| US6369216B1 (en) | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| US7022685B2 (en) | 1998-09-25 | 2006-04-04 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
| CN102276753A (en) * | 2011-09-13 | 2011-12-14 | 陕西理工学院 | Method for preparing polyporus selenium polysaccharide |
-
1979
- 1979-11-27 JP JP15315979A patent/JPS5676401A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU647751B2 (en) * | 1989-09-08 | 1994-03-31 | Alpha-Beta Technology, Inc. | Method for immune system activation |
| US5322841A (en) * | 1989-09-08 | 1994-06-21 | Alpha-Beta Technology, Inc. | Method for producing neutral glucans for pharmaceutical applications |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| US5532223A (en) * | 1989-09-08 | 1996-07-02 | Alpha-Beta Technology, Inc. | Use of aqueous soluble glucan preparations to stimulate platelet production |
| US5849720A (en) * | 1989-09-08 | 1998-12-15 | Alpha-Beta Technology, Inc. | Enhancement of non-specific immune defenses by administration of underivatized, aqueous soluble glucans |
| US5811542A (en) * | 1989-09-08 | 1998-09-22 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US5633369A (en) * | 1989-09-08 | 1997-05-27 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US5663324A (en) * | 1989-09-08 | 1997-09-02 | Alpha-Beta Technology, Inc. | Method for producing underivatized, aqueous soluble β(1-3) glucan |
| US5783569A (en) * | 1992-08-21 | 1998-07-21 | Alpha-Beta Technology, Inc. | Uses for underivatized, aqueous soluble β(1-3) glucan and compositions comprising same |
| US5817643A (en) * | 1992-08-21 | 1998-10-06 | Alpha-Beta Technology, Inc. | Underivatized, aqueous soluable β(1-3) glucan, composition and method of making same |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| US6046323A (en) * | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
| US6369216B1 (en) | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| US7022685B2 (en) | 1998-09-25 | 2006-04-04 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
| US7566704B2 (en) | 1998-09-25 | 2009-07-28 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
| CN102276753A (en) * | 2011-09-13 | 2011-12-14 | 陕西理工学院 | Method for preparing polyporus selenium polysaccharide |
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